한빛사논문
- 조회227
Jihei Sara Lee M.D. 1 ∗, Seung Won Lee M.D., Ph.D. 2 ∗, Nang Kyeong Lee M.Sc. 3, Yong Joon Kim M.D., Ph.D. 1 †, Hyoung Won Bae M.D., Ph.D. 1, Chan Yun Kim M.D., Ph.D. 1 †
1Department of Ophthalmology, Institute of Vision Research, College of Medicine, Yonsei University, Severance Hospital, Seoul, Republic of Korea
2Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon, Republic of Korea
3Department of Computer Science and Engineering, Sungkyunkwan University, Suwon, Republic of Korea
∗J.S. Lee and S.W. Lee equally contributed to this work as co-first authors
†Y.J. Kim and C.Y. Kim equally contributed to this work as co-corresponding authors
Abstract
Purpose: To determine the risk of optic neuritis (ON) during non-pharmaceutical interventions (NPI), vaccination and infection phase of coronavirus disease-19 (COVID-19) in comparison to pre-outbreak levels in pediatric and adult populations in South Korea.
Design: A nationwide, population-based, retrospective study.
Participants: South Korean individuals with a primary diagnosis of ON between January 2017 and December 2022.
Methods: The Korean Health Insurance Review and Assessment database was queried for new diagnoses of ON between January 2017 and December 2022. Data were divided into 4 periods: pre-COVID-19 (2017-2019), NPI (2020), nationwide vaccination (2021) and nationwide infection (2022). The risk of ON development for each period was calculated and compared to pre-COVID-19 levels with 95% confidence intervals (CI) reported.
Main outcome measures: Incidence rate ratio (IRR) of ON for each period.
Results: A total of 7,216 patients (52.7 % females) were included in the study, with 3,770 patients diagnosed with ON pre-COVID-19 (2017-2019), 1,193 patients during NPI, 1,135 patients during the vaccination and 1,118 patients during the infection phases. The annual incidence of ON during NPI (IRR 0.92 (95% CI 0.85-1.00), P=0.043), vaccination (IRR 0.88 (95% CI 0.81-0.95), P=0.001) and infection (IRR 0.86 (95% CI 0.80-0.93), P<0.001) phases significantly decreased compared to pre-COVID-19 levels when adjusted for age and sex. The proportions of diagnosis with multiple sclerosis (MS), neuromyelitis optica (NMO), and acute disseminated encephalomyelitis (ADEM) among patients who developed ON significantly increased in 2021 in comparison to the pre-outbreak levels (9.87% vs. 5.81%; P=0.0002).
Conclusions: The risks of ON development during NPI, vaccination and infection phases of COVID-19 did not increase in comparison to the pre-outbreak levels in general population. However, COVID-19 vaccination may be associated with increased risks of ON associated with diseases such as ADEM, MS and NMOSD.
논문정보
- Research article
- 2024년 09월 (BRIC 등록일 2024-09-19)
- 국내 연구진
- 의약학 > 응용의학
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