오세용 (한양대학교 ERICA)

한빛사논문

조회232

한양대학교 ERICA

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Sci. Adv., Sep 13 2024, 10 (37) | https://doi.org/10.1126/sciadv.ado7089 Simultaneous electromechanical monitoring in engineered heart tissues using a mesoscale framework

Dominic E. Fullenkamp ^1†, Woo-Youl Maeng ^2,3†, Seyong Oh^4†, Haiwen Luan^2,3,5, Kyung Su Kim ^2,3,6,7, Ivana A Chychula ¹, Jin-Tae Kim ^2,3,8, Jae-Young Yoo ⁹, Cory W Holgren ¹, Alexis R. Demonbreun ¹, Sharon George ^10,11, Binjie Li ¹⁰, Yaching Hsu ^2,3,10, Gooyoon Chung ¹², Jeongmin Yoo ¹², Jahyun Koo^6,7, Yoonseok Park ^12,13*, Igor R. Efimov ^10,14*, Elizabeth M. McNally^1*, John A. Rogers ^{2,3,10,15,16*}

¹Center for Genetic Medicine, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

²Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.

³Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.

⁴Division of Electrical Engineering, Hanyang University ERICA, Ansan 15588, Republic of Korea.

⁵Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA 92093, USA.

⁶School of Biomedical Engineering, Korea University, Seoul 02841, Republic of Korea.

⁷Interdisciplinary Program in Precision Public Health, Korea University, Seoul 02841, Republic of Korea.

⁸Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea.

⁹Department of Semiconductor Convergence Engineering, Sungkyunkwan University, Suwon 16417, Republic of Korea.

¹⁰Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.

¹¹Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA.

¹²Department of Advanced Materials Engineering for Information and Electronics, Integrated Education Institute for Frontier Science & Technology (BK21 Four), Kyung Hee University, Yongin 17104, Republic of Korea.

¹³KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul 02447, Republic of Korea.

¹⁴Department of Medicine, Northwestern University, Chicago, IL 60611, USA.

¹⁵Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

¹⁶Department of Neurological Surgery, Northwestern University, Chicago, IL 60611, USA.

*Corresponding authors: Y.P., I.R.E., E.M.M., J.A.R.

^†These authors contributed equally to this work.

Abstract

Engineered heart tissues (EHTs) generated from human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) represent powerful platforms for human cardiac research, especially in drug testing and disease modeling. Here, we report a flexible, three-dimensional electronic framework that enables real-time, spatiotemporal analysis of electrophysiologic and mechanical signals in EHTs under physiological loading conditions for dynamic, noninvasive, longer-term assessments. These electromechanically monitored EHTs support multisite measurements throughout the tissue under baseline conditions and in response to stimuli. Demonstrations include uses in tracking physiological responses to pharmacologically active agents and in capturing electrophysiological characteristics of reentrant arrhythmias. This platform facilitates precise analysis of signal location and conduction velocity in human cardiomyocyte tissues, as the basis for a broad range of advanced cardiovascular studies.

논문정보

형식Research article
게재일2024년 09월 (BRIC 등록일 2024-09-12)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오소재

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