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Plant Physiol., Sep 11 2024, kiae426 | https://doi.org/10.1093/plphys/kiae426
How coat proteins shape autophagy in plant cells
Taijoon Chung 1,2*, Ye Eun Choi 1, Kyoungjun Song 1, Hyera Jung 1,2
1Department of Biological Sciences, Pusan National University, Busan, 46241, Republic of Korea.
2Institute of Systems Biology, Pusan National University, Busan, 46241, Republic of Korea.
*Author for correspondence: Taijoon Chung
Abstract
Autophagy is a membrane trafficking pathway through which eukaryotic cells target their own cytoplasmic constituents for degradation in the lytic compartment. Proper biogenesis of autophagic organelles requires a conserved set of autophagy-related (ATG) proteins and their interacting factors, such as signalling phospholipid phosphatidylinositol 3-phosphate (PI3P) and coat complex II (COPII). The COPII machinery, which was originally identified as a membrane coat involved in the formation of vesicles budding from the endoplasmic reticulum, contributes to the initiation of autophagic membrane formation in yeast, metazoan, and plant cells; however, the exact mechanisms remain elusive. Recent studies using the plant model species Arabidopsis thaliana have revealed that plant-specific PI3P effectors are involved in autophagy. The PI3P effector FYVE2 interacts with the conserved PI3P effector ATG18 and with COPII components, indicating an additional role for the COPII machinery in the later stages of autophagosome biogenesis. In this Update, we examined recent research on plant autophagosome biogenesis and proposed working models on the functions of the COPII machinery in autophagy, including its potential roles in stabilizing membrane curvature and sealing the phagophore.
논문정보
- Review Paper
- 2024년 09월 (BRIC 등록일 2024-09-12)
- 국내 연구진
- 생명과학 > 세포생물학
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