한빛사논문
- 조회57
Yeshin Kim1, Yaakov Stern2, Sang Won Seo3,4,5, Duk L. Na3,6, Jae-Won Jang1, Hyemin Jang7, Cognitive Reserve Research Group of Korea Dementia Association
1Department of Neurology, Kangwon National University College of Medicine, Chuncheon, Republic of Korea
2Cognitive Neuroscience Division, Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA
3Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
4Samsung Alzheimer’s Convergence Research Center, Samsung Medical Center, Seoul, Republic of Korea
5Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea, Seoul, Republic of Korea
6Happymind Clinic, Seoul, Republic of Korea
7Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea
Jae-Won Jang and Hyemin Jang authors contributed equally to this work.
Correspondence : Hyemin Jang, Jae-Won Jang
Abstract
Introduction: We investigated distinctive factors associated with cognitive reserve (CR) based on education level.
Methods: Among 1247 participants who underwent neuropsychological assessment, amyloid positron emission tomography, and brain magnetic resonance imaging, 336 participants with low education (≤6 years) and 697 with high education (≥12 years) were selected. CR was measured as the difference between the predicted and observed value of cognitive function based on cortical thickness. Multiple linear regression was conducted in each group after controlling for age and sex.
Results: In the low-education group, low literacy, long sleep duration(>8 h/day), and diabetes were negatively associated with CR, whereas cognitive and physical activity were positively associated with CR. In the high-education group, cognitive activity was positively related to CR, whereas low literacy, long sleep duration (> 8 h/day), and depression were negatively related to CR.
Discussion: This study provides insights into different strategies for enhancing CR based on educational background.
Highlights: Factors associated with cognitive reserve (CR) varied according to the education level. Diabetes and physical activity were associated with CR in the low-education group. Depression was related to CR in the high-education group. Low literacy, sleep duration, and cognitive activity were associated with CR in both groups. Dementia-prevention strategies should be tailored according to educational level.
논문정보
- Research article
- 2024년 09월 (BRIC 등록일 2024-09-12)
- 국내(교신)+국외 연구진
- 의약학 > 응용의학
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