신윤수 (기초과학연구원, 서울대학교) | 한빛사논문 > 한빛사

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조회286

기초과학연구원, 서울대학교

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Biomaterials, Sep 03 2024, 314 S0142-9612(24)00336-3 | https://doi.org/10.1016/j.biomaterials.2024.122802 Functional-hydrogel-based electronic-skin patch for accelerated healing and monitoring of skin wounds

Yoonsoo Shin ^a,b,1, Hyun Su Lee ^a,b,1, Jeong-Uk Kim ^b,1, Young-Hyeon An^c, Ye-Sol Kim ^b, Nathaniel S. Hwang^b,c,d, Dae-Hyeong Kim ^a,b

^aCenter for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, 08826, Republic of Korea

^bSchool of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul, 08826, Republic of Korea

^cBioMax/N-Bio Institute, Institute of Bio Engineering, Seoul National University, Seoul, 08826, Republic of Korea

^dInstitute of Engineering Research, Seoul National University, Seoul, 08826, Republic of Korea

¹These authors contributed equally to this work.

Corresponding authors: Nathaniel S. Hwang, Dae-Hyeong Kim

Abstract

Conductive hydrogels feature reasonable electrical performance as well as tissue-like mechanical softness, thus positioning them as promising material candidates for soft bio-integrated electronics. Despite recent advances in materials and their processing technologies, however, facile patterning and monolithic integration of functional hydrogels (e.g., conductive, low-impedance, adhesive, and insulative hydrogels) for all-hydrogel-based soft bioelectronics still poses significant challenges. Here, we report material design, fabrication, and integration strategies for an electronic-skin (e-skin) patch based on functional hydrogels. The e-skin patch was fabricated by using photolithography-compatible functional hydrogels, such as poly(2-hydroxyethyl acrylate) (PHEA) hydrogel (substrate), Ag flake hydrogel (interconnection; conductivity: ∼571.43 S/cm), poly(3,4-ethylenedioxythiophene:polystyrene) (PEDOT:PSS) hydrogel (working electrode; impedance: ∼69.84 Ω @ 1 Hz), polydopamine (PDA) hydrogel (tissue adhesive; shear strength: ∼725.1 kPa), and poly(vinyl alcohol) (PVA) hydrogel (encapsulation). The properties of these functional hydrogels closely resemble those of human tissues in terms of water content and Young's modulus, enabling stable tissue-device interfacing in dynamically changing physiological environments. We demonstrated the efficacy of the e-skin patch through its application to accelerated healing and monitoring of skin wounds in mouse models - efficient fibroblast migration, proliferation, and differentiation promoted by electric field (EF) stimulation and iontophoretic drug delivery, and monitoring of the accelerated healing process through impedance mapping. The all-hydrogel-based e-skin patch is expected to create new opportunities for various clinically-relevant tissue interfacing applications.

논문정보

형식Research article
게재일2024년 09월 (BRIC 등록일 2024-09-11)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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