최영환 (서울대학교, Johns Hopkins School of Medicine) | 한빛사논문 > 한빛사

한빛사논문

조회307

서울대학교, Johns Hopkins School of Medicine

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Bioact. Mater., Oct 2024, 40 | https://doi.org/10.1016/j.bioactmat.2024.08.001 Mussel-inspired sulfated hyaluronan cryogel patch with antioxidant, anti-inflammatory, and drug-loading properties for multifunctional wound adhesives

Wonmoon Song ^a,b,1, Young Hwan Choi ^a,c,d,1, Young Gi Moon ^a, Changyub Lee ^a, M. Nivedhitha Sundaram^a, Nathaniel S. Hwang^a,b,c,e

^aSchool of Chemical and Biological Engineering, Institute for Chemical Processes, Seoul National University, Seoul, 08826, Republic of Korea

^bInterdisciplinary Program in Bioengineering, Seoul National University, Seoul, 08826, Republic of Korea

^cBio-MAX/N-Bio Institute, Institute of BioEngineering, Seoul National University, Seoul, 08826, Republic of Korea

^dDivision of Pediatric Cardiac Surgery, Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA

^eInstitute of Engineering Research, Seoul National University, Seoul, 08826, Republic of Korea

¹These authors contributed equally to this study.

Corresponding author: Nathaniel S. Hwang

Abstract

Wounds, characterized by the disruption of the continuity of body tissues resulting from external trauma, manifest in diverse types and locations. Although numerous wound dressings are available for various wound scenarios, it remains challenging to find an integrative wound dressing capable of addressing diverse wound situations. We focused on utilizing sulfated hyaluronan (sHA), known for its anti-inflammatory properties and capacity to load cationic drugs. By conjugating catechol groups to sHA (sHA-CA), we achieved several advantages in wound healing: 1) Fabrication of patches through crosslinking with catechol-modified high-molecular-weight hyaluronan (HA(HMW)-CA), 2) Adhesiveness that enabled stable localization, 3) Radical scavenging that could synergize with the immunomodulation of sHA. The sHA-CA patches demonstrated therapeutic efficacy in three distinct murine wound models: diabetic wound, hepatic hemorrhage, and post-surgical adhesion. Collectively, these findings underscore the potential of the sHA-CA patch as a promising candidate for the next-generation wound dressing.

논문정보

형식Research article
게재일2024년 10월 (BRIC 등록일 2024-09-10)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오소재

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