진효준 (아주대학교 의과대학)

한빛사논문

조회64

아주대학교 의과대학

Biochim. Biophys. Acta-Rev. Cancer, Sep 04 2024, S0304-419X(24)00109-4 | https://doi.org/10.1016/j.bbcan.2024.189178 Matrisomics: Beyond the extracellular matrix for unveiling tumor microenvironment

Jiwon Hong^a,b,1, Hyo Joon Jin ^a,1, Mi Ran Choi ^a,1, Darren Wan-Teck Lim ^c, Jong-Eun Park ^d, You-Sun Kim ^a,b, Su Bin Lim ^a,b

^aDepartment of Biochemistry & Molecular Biology, Ajou University School of Medicine, Suwon 16499, Republic of Korea

^bDepartment of Biomedical Sciences, Graduate School of Ajou University, Suwon 16499, Republic of Korea

^cDivision of Medical Oncology, National Cancer Centre, Singapore 168583, Singapore

^dGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-Ro, Yuseong-Gu, Daejeon 34141, Republic of Korea

¹These authors contributed equally to this work.

Corresponding author : Su Bin Lim

Abstract

The matrisome, a group of proteins constituting or interacting with the extracellular matrix (ECM), has garnered attention as a potent regulator of cancer progression. An increasing number of studies have focused on cancer matrisome utilizing diverse -omics approaches. Here, we present diverse patterns of matrisomal populations within cancer tissues, exploring recent -omics studies spanning different '-omics' levels (epigenomics, genomics, transcriptomics, and proteomics), as well as newly developed sequencing techniques such as single-cell RNA sequencing and spatial transcriptomics. Some matrisome genes showed uniform patterns of upregulated or downregulated expression across various cancers, while others displayed different expression patterns according to the cancer types. This matrisomal dysregulation in cancer was further examined according to their originating cell type and spatial location in the tumor tissue. Experimental studies were also collected to demonstrate the identified roles of matrisome genes during cancer progression. Interestingly, many studies on cancer matrisome have suggested matrisome genes as effective biomarkers in cancer research. Although the specific mechanisms and clinical applications of cancer matrisome have not yet been fully elucidated, recent techniques and analyses on cancer matrisomics have emphasized their biological importance in cancer progression and their clinical implications in deciding the efficacy of cancer treatment.

논문정보

형식Review Paper
게재일2024년 09월 (BRIC 등록일 2024-09-09)
연구진국내(교신)+국외 연구진
분야 생명과학 > 유전자발현

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