고규영 (KAIST, 기초과학연구원)

한빛사논문

조회573

KAIST, 기초과학연구원

CV File 258 kb

Cell, Sep 05 2024, 187 (18) S0092-8674(24)00772-4 | https://doi.org/10.1016/j.cell.2024.07.012 A systems view of the vascular endothelium in health and disease

Hellmut G. Augustin ^1,2,5, Gou Young Koh ^3,4,5

¹European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany

²Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ), 69120 Heidelberg, Germany

³Center for Vascular Research, Institute for Basic Science (IBS), Daejeon 34141, Republic of Korea

⁴Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea

⁵These authors contributed equally.

Corresponding authors: Hellmut G. Augustin, Gou Young Koh

Abstract

The dysfunction of blood-vessel-lining endothelial cells is a major cause of mortality. Although endothelial cells, being present in all organs as a single-cell layer, are often conceived as a rather inert cell population, the vascular endothelium as a whole should be considered a highly dynamic and interactive systemically disseminated organ. We present here a holistic view of the field of vascular research and review the diverse functions of blood-vessel-lining endothelial cells during the life cycle of the vasculature, namely responsive and relaying functions of the vascular endothelium and the responsive roles as instructive gatekeepers of organ function. Emerging translational perspectives in regenerative medicine, preventive medicine, and aging research are developed. Collectively, this review is aimed at promoting disciplinary coherence in the field of angioscience for a broader appreciation of the importance of the vasculature for organ function, systemic health, and healthy aging.

논문정보

형식Review Paper
게재일2024년 09월 (BRIC 등록일 2024-09-11)
연구진국내(교신)+국외 연구진
분야 의약학 > 재생의학

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