김치경 (고려대학교 구로병원)

한빛사논문

조회98

고려대학교 구로병원

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Adv. Healthc. Mater., Sep 05 2024, | https://doi.org/10.1002/adhm.202401994 Orally Deliverable Iron-Ceria Nanotablets for Treatment of Inflammatory Bowel Disease

Seungmin Baik ^1,2, Hyunmin Kim ^3,4, Yunjung Lee^1,2, Taegyu Kang^1,2, Kwangsoo Shin ^1,2, Changyeong Song ^1,2, Ok Kyu Park^2,5, Byeonggeun Kang ⁶, Nohyun Lee^2,7, Dokyoon Kim ^2,8, Seung Hong Choi ^2,5,9, Seung Han Kim ¹⁰, Min Soh ^1,9, Taeghwan Hyeon^1,2, Chi Kyung Kim^3,4

¹School of Chemical and Biological Engineering and Institute of Chemical Process, Seoul National University, Seoul, 08826, Republic of Korea.

²Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, 08826, Republic of Korea.

³Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, 08308, Republic of Korea.

⁴Department of Medical Science, BK21 Plus KUMS Graduate Program, Korea University College of Medicine, Seoul, 08308, Republic of Korea.

⁵Department of Radiology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.

⁶Bio-MAX Institute, Seoul National University, Seoul, 08826, Republic of Korea.

⁷School of Advanced Materials Engineering, Kookmin University, Seoul, 02707, Republic of Korea.

⁸Department of Bionano Engineering and Bionanotechnology, Hanyang University, Ansan, 15558, Republic of Korea.

⁹Center for Advanced Pharmaceutical Technology, HyeonTechNBio Inc., Seoul, 08826, Republic of Korea.

¹⁰Department of Gastroenterology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, 08308, Republic of Korea.

S.B., H.K., and Y.L. contributed equally to this work.

Corresponding Authors: Min Soh, Taeghwan Hyeon, Chi Kyung Kim

Abstract

Ceria-based nanoparticles are versatile in treating various inflammatory diseases, but their feasibility in clinical translation is undermined by safety concerns and a limited delivery system. Meanwhile, the idiopathic nature of inflammatory bowel disease (IBD) calls for a wider variety of therapeutics via moderation of the intestinal immune system. In this regard, the synthesis and oral formulation of iron-ceria nanoparticles (CF NPs) with enhanced nanozymic activity and lower toxicity risk than conventional ceria-based nanoparticles are reported. CF NPs are clustered in calcium phosphate (CaP) and coated with a pH-responsive polymer to provide the enteric formulation of iron-ceria nanotablets (CFNT). CFNT exhibits a marked alleviative efficacy in the dextran sodium sulfate (DSS)-induced enterocolitis model in vivo by modulating the pro-inflammatory behavior of innate immune cells including macrophages and neutrophils, promoting anti-inflammatory cytokine profiles, and downregulating key transcription factors of inflammatory pathways.

논문정보

형식Research article
게재일2024년 09월 (BRIC 등록일 2024-09-06)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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