김민서 (Broad Institute of MIT and Harvard/Massachusetts General Hospital)

한빛사논문

조회192

Broad Institute of MIT and Harvard/Massachusetts General Hospital

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Obes. Rev. , Sep 04 2024, | https://doi.org/10.1111/obr.13823 Integration of observational and causal evidence for the association between adiposity and 17 gastrointestinal outcomes: An umbrella review and meta-analysis

Min Seo Kim ^1,2, Inhyeok Lee ³, Pradeep Natarajan ^2,4,5, Ron Do ^6,7, Yeongkeun Kwon ³, Jae Il Shin ⁸, Marco Solmi ^{9,10,11,12,13}, Jong Yeob Kim¹⁴, Hong-Hee Won ^14,15, Sungsoo Park ³

¹Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA

²Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA

³Division of Foregut Surgery, Korea University College of Medicine, Seoul, Republic of Korea

⁴Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA, USA

⁵Department of Medicine, Harvard Medical School, Boston, MA, USA

⁶The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA

⁷Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA

⁸Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea

⁹Department of Psychiatry, University of Ottawa, Ontario, Canada

¹⁰Department of Mental Health, The Ottawa Hospital, Ontario, Canada

¹¹Ottawa Hospital Research Institute (OHRI) Clinical Epidemiology Program, University of Ottawa, Ontario, Canada

¹²School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada

¹³Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany

¹⁴Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, Republic of Korea

¹⁵Samsung Genome Institute, Samsung Medical Center, Seoul, Republic of Korea

Min Seo Kim and Inhyeok Lee contributed equally to this work.

Correspondence : Sungsoo Park, Hong-Hee Won

Abstract

We systematically reviewed observational and Mendelian randomization (MR) articles that evaluated the association between obesity and 17 gastrointestinal (GI) diseases to integrate causal and observational evidence. A total of 594 observational studies from 26 systematic reviews and meta-analyses and nine MR articles were included. For every 5 kg/m² increase in body mass index (BMI), there was an increased risk of GI diseases ranging from 2% for rectal cancer (relative risk [RR]: 1.02, 95% confidence interval [CI]: 1.01 to 1.03) to 63% for gallbladder disease (RR: 1.63, 95% CI: 1.50 to 1.77). MR articles indicated that risks of developing GI diseases elevated with each 1 standard deviation increase in genetically predicted BMI, ranging from 11% for Crohn's disease to 189% for nonalcoholic fatty liver disease. Moreover, upper GI conditions were less susceptible, whereas hepatobiliary organs were more vulnerable to increased adiposity. Among the associations between obesity and the 17 GI conditions, causal relationships were inferred from only approximately half (10/17, 59%). This study reveals a substantial gap between observational and causal evidence, indicating that a combined approach is necessary to effectively inform public health policies and guide epidemiological research on obesity and GI diseases.

논문정보

형식Review Paper
게재일2024년 09월 (BRIC 등록일 2024-09-06)
연구진국내(교신)+국외 연구진
분야 의약학 > 응용의학

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