이정렬 (서울대학교 의과대학)

한빛사논문

조회142

서울대학교 의과대학

CV File 258 kb

Biomaterials, Aug 30 2024, 313 S0142-9612(24)00302-8 | https://doi.org/10.1016/j.biomaterials.2024.122768 Local delivery of platelet-derived factors mitigates ischemia and preserves ovarian function through angiogenic modulation: A personalized regenerative strategy for fertility preservation

Nanum Chung ^a,b, Chungmo Yang ^b,e, Heeseon Yang ^a,b, Jungwoo Shin ^a,b, Chae Young Song ^a,b, Hyewon Min ^a,b, Ji Hyang Kim ^d, Kangwon Lee^f, Jung Ryeol Lee^a,b,c

^aDepartment of Translational Medicines, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea

^bDepartment of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, 13620, Republic of Korea

^cDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea

^dDepartment of Obstetrics and Gynecology, Fertility Center of CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, 13496, Republic of Korea

^eProgram in Nanoscience and Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea

^fDepartment of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea

Corresponding authors: Ji Hyang Kim, Kangwon Lee, Jung Ryeol Lee

Abstract

As the most prominent and ideal modality in female fertility preservation, ovarian tissue cryopreservation, and transplantation often confront the challenge of ischemic damage and follicular loss from avascular transplantation. To surmount this impediment, we engineered a novel platelet-derived factors-encapsulated fibrin hydrogel (PFH), a paradigmatic biomaterial. PFH encapsulates autologous platelet-derived factors, utilizing the physiological blood coagulation cascade for precise local delivery of bioactive molecules. In our study, PFH markedly bolstered the success of avascular ovarian tissue transplantation. Notably, the quantity and quality of follicles were preserved with improved neovascularization, accompanied by decreased DNA damage, increased ovulation, and superior embryonic development rates under a Low-concentration Platelet-rich plasma-derived factors encapsulated fibrin hydrogel (L-PFH) regimen. At a stabilized point of tissue engraftment, gene expression analysis mirrored normal ovarian tissue profiles, underscoring the effectiveness of L-PFH in mitigating the initial ischemic insult. This autologous blood-derived biomaterial, inspired by nature, capitalizes on the blood coagulation cascade, and combines biodegradability, biocompatibility, safety, and cost-effectiveness. The adjustable properties of this biomaterial, even in injectable form, extend its potential applications into the broader realm of personalized regenerative medicine. PFH emerges as a promising strategy to counter ischemic damage in tissue transplantation, signifying a broader therapeutic prospect. (197 words).

논문정보

형식Research article
게재일2024년 08월 (BRIC 등록일 2024-09-06)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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