한빛사
>
한빛사논문
한빛사논문
- 조회207
J. Exp. Med., Oct 07 2024, 221 (10) e20230893 | https://doi.org/10.1084/jem.20230893
Transcriptional network dynamics in early T cell development
Boyoung Shin 1, Samantha J Chang 1, Brendan W MacNabb 1, Ellen V Rothenberg 1
1Division of Biology and Biological Engineering California Institute of Technology , Pasadena, CA, USA.
Correspondence to Ellen V. Rothenberg
Abstract
The rate at which cells enter the T cell pathway depends not only on the immigration of hematopoietic precursors into the strong Notch signaling environment of the thymus but also on the kinetics with which each individual precursor cell reaches T-lineage commitment once it arrives. Notch triggers a complex, multistep gene regulatory network in the cells in which the steps are stereotyped but the transition speeds between steps are variable. Progenitor-associated transcription factors delay T-lineage differentiation even while Notch-induced transcription factors within the same cells push differentiation forward. Progress depends on regulator cross-repression, on breaching chromatin barriers, and on shifting, competitive collaborations between stage-specific and stably expressed transcription factors, as reviewed here.
논문정보
- Review Paper
- 2024년 10월 (BRIC 등록일 2024-09-05)
- 국외 연구진
댓글 작성 로그인
팝업 닫기관련 링크
연구자 ID
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
