한빛사논문
- 조회51
Panchanathan Manivasagan a, Thavasyappan Thambi b, Ara Joe a, Hyo-Won Han a, Sun-Hwa Seo a, Yeong Jun Jeon a, João Conde c, Eue-Soon Jang a
aDepartment of Applied Chemistry, Kumoh National Institute of Technology, Daehak-ro 61, Gumi, Gyeongbuk 39177, Republic of Korea
bGraduate School of Biotechnology, College of Life Sciences, Kyung Hee University, Yongin-si, Gyeonggi-do 17104, Republic of Korea
cToxOmics, NOVA Medical School, Faculdade de Ciências Médicas, NMS|FCM, Universidade NOVA de Lisboa, Lisboa, Portugal
Corresponding authors : João Conde, Eue-Soon Jang
Abstract
The prevalence of multidrug-resistant (MDR) bacterial infections has emerged as a serious threat to clinical treatment and global human health, and has become one of the most important challenges in clinical therapy. Hence, there is an urgent need to develop safe, effective, and new antibacterial strategies based on multifunctional nanomaterials for the accurate detection and treatment of MDR bacterial infections. Chemodynamic therapy (CDT) is an emerging antibacterial therapeutic strategy that uses Fenton/Fenton-like metal-based nanocatalysts to convert hydrogen peroxide (H2O2) into hydroxyl radicals (radical dotOH) to destroy MDR bacterial infections. Despite the enormous potential of CDT, a single CDT has limitations such as low catalytic efficacy and insufficient production of H2O2. In this regard, CDT can be combined with other antibacterial strategies, such as photothermal therapy (PTT), in which CDT efficacy can be effectively enhanced by the PTT heating effect. Thus, the rational combination of PTT and CDT into one nanoplatform has been demonstrated as a highly efficient antibacterial strategy for achieving a better therapeutic effect. This review summarizes and discusses the latest advances in photothermal-enhanced CDT (PT/CDT) based on multifunctional nanomaterials for bacterial infection theranostics as well as the advantages, challenges, and future research directions for clinical applications, which will inspire the development of new PT/CDT based on metal-based photothermal nanocatalysts for future bacterial infection theranostics.
논문정보
- Review Paper
- 2024년 08월 (BRIC 등록일 2024-09-05)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오소재
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