한빛사논문
- 조회81
Seo Young Yun1, Joo Young Yun1, Chaeseong Lim2, Hyeoncheol Oh2, Eunjeong Son3, Kihyuk Shin4,5,6, Kihun Kim7,8, Dai Sik Ko9, Yun Hak Kim7,8
1School of Medicine, Pusan National University, Yangsan, Republic of Korea
2Occupational and Environmental Medicine, Kosin University Gospel Hospital, Busan, Republic of Korea
3Division of Respiratory and Allergy, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
4Department of Dermatology, College of Medicine, Pusan National University, Busan, Republic of Korea
5Department of Dermatology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
6Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
7Department of Biomedical Informatics, School of Medicine, Pusan National University, Yangsan, Republic of Korea
8Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea
9Division of Vascular Surgery, Department of General Surgery, Gachon University College of Medicine, Gil Medical Center, Incheon, Republic of Korea
Seo Young Yun and Joo Young Yun contribute equally to this work.
Correspondence : Kihun Kim, Dai Sik Ko, Yun Hak Kim
Abstract
Obesity is a major public health concern associated with a higher risk of various comorbidities. Some studies have explored the impact of obesity on cognitive function and, conversely, how lower intelligence might increase the risk of later obesity. The aim of this study is to analyze a complex relationship between body mass index (BMI) and intelligence quotient (IQ), employing a comprehensive approach, including a systematic review, meta-analysis, and Mendelian randomization (MR). We extracted the data from Medline and Embase to identify relevant studies published since June 22, 2009. MR analysis relied on genetic databases such as the Genome-Wide Association Study (GWAS) and the Genetic Investigation of Anthropometric Traits (GIANT) to explore potential causal relationships. The systematic review and meta-analysis encompassed 34 and 17 studies, respectively. They revealed a substantial correlation between obesity and reduced IQ, particularly notable among school-age children (mean difference −5.26; 95% CI: −7.44 to −3.09). Notably, within the IQ subgroup, verbal IQ also exhibited a significant association with a mean difference of −7.73 (95% CI: −14.70 to −0.77) in school-age children. In contrast, the MR did not unveil a significant causal relationship between BMI and IQ, both in childhood and adulthood. This comprehensive analysis underscores a significant correlation between BMI and IQ, particularly in school-age children. However, the MR analysis implies a potentially weaker causal relationship. Future large-scale cohort studies should address potential confounding factors to provide further insights into the BMI-IQ relationship.
논문정보
- Review Paper
- 2024년 09월 (BRIC 등록일 2024-09-04)
- 국내 연구진
- 의약학 > 응용의학
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