N Sanoj Rejinold (단국대학교)

한빛사논문

조회34

N Sanoj RejinoldN Sanoj Rejinold

단국대학교

Nano Lett., Aug 28 2024, | https://doi.org/10.1021/acs.nanolett.4c02845 Insight into Preventing Global Dengue Spread: Nanoengineered Niclosamide for Viral Infections

N Sanoj Rejinold^1,2, Geun-Woo Jin ³, Jin-Ho Choy^1,4,5

¹Intelligent Nanohybrid Materials Laboratory (INML), College of Medicine, Dankook University, Cheonan 31116, Republic of Korea.

²Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, 31116, Republic of Korea.

³R&D Center, Hyundai Bioscience Co. LTD., Seoul 03759, Republic of Korea.

⁴Division of Natural Sciences, The National Academy of Sciences, Seoul 06579, Republic of Korea.

⁵Tokyo Tech World Research Hub Initiative (WRHI), Institute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8503, Japan.

Corresponding Author : Jin-Ho Choy

Abstract

Millions of cases of dengue virus (DENV) infection yearly from Aedes mosquitoes stress the need for effective antivirals. No current drug effectively combats dengue efficiently. Transient immunity and severe risks highlight the need for broad-spectrum antivirals targeting all serotypes of DENV. Niclosamide, an antiparasitic, shows promising antiviral activity against the dengue virus, but enhancing its bioavailability is challenging. To overcome this issue and enable niclosamide to address the global dengue problem, nanoengineered niclosamides can be the solution. Not only does it address cost issues but also with its broad-spectrum antiviral effects nanoengineered niclosamide offers hope in addressing the current health crisis associated with DENV and will play a crucial role in combating other arboviruses as well.

논문정보

형식Review Paper
게재일2024년 08월 (BRIC 등록일 2024-09-11)
연구진국내(교신)+국외 연구진
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