여윤 (Purdue University)

한빛사논문

조회74

Purdue University

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Adv. Drug Deliv. Rev., Aug 31 2024, S0169-409X(24)00267-9 | https://doi.org/10.1016/j.addr.2024.115445 Effects of nanoparticle deformability on multiscale biotransport

Hytham H. Gadalla ^a,b, Zhongyue Yuan ^a, Ziang Chen^a, Faisal Alsuwayyid ^a,c, Subham Das ^d, Harsa Mitra^d, Arezoo M. Ardekani ^d, Ryan Wagner^d, Yoon Yeo ^a,e,f

^aDepartment of Industrial and Molecular Pharmaceutics, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA

^bDepartment of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

^cDepartment of Pharmaceutical Sciences, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia

^dSchool of Mechanical Engineering, Purdue University, 585 Purdue Mall, West Lafayette, IN, 47907, USA

^ePurdue University Institute for Cancer Research, 201 South University Street, West Lafayette, IN, 47907, USA

^fWeldon School of Biomedical Engineering, Purdue University, 206 S Martin Jischke Drive, West Lafayette, IN 47907, USA

Corresponding author : Yoon Yeo

Abstract

Deformability is one of the critical attributes of nanoparticle (NP) drug carriers, along with size, shape, and surface properties. It affects various aspects of NP biotransport, ranging from circulation and biodistribution to interactions with biological barriers and target cells. Recent studies report additional roles of NP deformability in biotransport processes, including protein corona formation, intracellular trafficking, and organelle distribution. This review focuses on the literature published in the past five years to update our understanding of NP deformability and its effect on NP biotransport. We introduce different methods of modulating and evaluating NP deformability and showcase recent studies that compare a series of NPs in their performance in biotransport events at all levels, highlighting the consensus and disagreement of the findings. It concludes with a perspective on the intricacy of systematic investigation of NP deformability and future opportunities to advance its control toward optimal drug delivery.

논문정보

형식Review Paper
게재일2024년 08월 (BRIC 등록일 2024-09-04)
연구진국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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