나윤영 (POSTECH)

한빛사논문

조회56

나윤영Yunyoung Nah

POSTECH

J. Control. Release, Aug 29 2024, 374 S0168-3659(24)00573-X | https://doi.org/10.1016/j.jconrel.2024.08.026 Tailored small molecule for inflammation treatment: Dual scavenger targeting nitric oxide and reactive oxygen species

Yunyoung Nah ^a, Jaekwang Kim^b, Seohee Lee ^a, Won-Gun Koh ^c, Won Jong Kim ^a,b,d

^aDepartment of Chemistry, POSTECH-CATHOLIC Biomedical Engineering Institute, POSTECH, Pohang 37673, South Korea

^bSchool of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, South Korea

^cDepartment of Chemical and Biomolecular Engineering, College of Engineering, Yonsei University, Seoul 03722, Republic of Korea

^dOmniaMed Co., Ltd, Pohang 37666, Republic of Korea

Corresponding author : Won Jong Kim

Abstract

Inflammation-related diseases are often marked by elevated levels of nitric oxide (NO) and reactive oxygen species (ROS), which play important roles in the modulation of inflammation. However, the development of organic materials effective in managing NO/ROS levels has remained a challenge. This study introduces a novel organic compound, NmeGA, engineered to scavenge both NO and ROS. NmeGA ingeniously integrates N-methyl-1,2,-phenylenediamine (Nme), a NO scavenger, with gallic acid (GA), a ROS scavenger, through an amide bond, endowing it with enhanced scavenging capabilities over its individual component. This compound exhibits reduced toxicity and increased lipophilicity value, underlining its increased biological applicability and highlighting its potential as an inflammation management tool. Through in vitro studies on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, NmeGA displayed remarkable scavenging efficiency for NO and ROS, coupled with significant anti-inflammatory effects. In an LPS-induced peritonitis model, administration of NmeGA substantially decreased mortality rates, NO and ROS levels, and inflammatory cytokine concentrations. These findings highlight NmeGA's versatility as a therapeutic agent against various inflammatory diseases.

논문정보

형식Research article
게재일2024년 08월 (BRIC 등록일 2024-09-04)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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