정원기 (연세대학교)

한빛사논문

조회92

정원기Won Gi Chung

연세대학교

ACS Nano, Aug 21 2024, | https://doi.org/10.1021/acsnano.4c06607 Three-Dimensional Electrodes of Liquid Metals for Long-Term, Wireless Cardiac Analysis and Modulation

Sumin Kim ^1,2∇, Jakyoung Lee^1,2∇, Won Gi Chung ^1,2∇, Yeon-Mi Hong ^1,2, Wonjung Park ^1,2, Jung Ah Lim^3,4,5, Jang-Ung Park ^1,2,3,6,7*

¹Department of Materials Science and Engineering, Yonsei University, Seoul 03722, Republic of Korea.

²Center for NanoMedicine, Institute for Basic Science (IBS), Seoul 03722, Republic of Korea.

³Yonsei-KIST Convergence Research Institute, Seoul 03722, Republic of Korea.

⁴Soft Hybrid Materials Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.

⁵Division of Nanoscience and Technology, KIST School, University of Science and Technology (UST), Seoul 02792, Republic of Korea.

⁶Graduate Program of Nano Biomedical Engineering (NanoBME), Advanced Science Institute, Yonsei University, Seoul 03722, Republic of Korea.

⁷Department of Neurosurgery, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.

∇S.K., J.L. and W.G.C. contributed equally to this work.

Corresponding Author : Jang-Ung Park

Abstract

Cardiovascular disease is a major public health issue, and smart diagnostic approaches play an important role in the analysis of electrocardiograms. Here, we present three-dimensional, soft electrodes of liquid metals that can be conformably attached to the surfaces of the heart and skin for long-term cardiac analysis. The fine micropillar structures of biocompatible liquid metals enable precise targeting to small tissue areas, allowing for spatiotemporal mapping and modulation of cardiac electrical activity with high resolution. The low mechanical modulus of these liquid-metal electrodes not only helps avoid inflammatory responses triggered by modulus mismatch between the tissue and electrodes, but also minimizes pain when embedded in biological tissues such as the skin and heart. Furthermore, in vivo experiments with animal models and human trials demonstrate long-term and accurate monitoring of electrocardiograms over a period of 30 days.

논문정보

형식Research article
게재일2024년 08월 (BRIC 등록일 2024-09-04)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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