한빛사논문
- 조회187
Sang Won Lee1,2∗, Seungho Kim3∗, Yongmin Chang4,5∗, Hyunsil Cha6, Ralph Noeske7, Changho Choi8, Seung Jae Lee1,9
1Department of Psychiatry, School of Medicine, Kyungpook National University, Daegu, Korea
2Department of Psychiatry, Kyungpook National University Chilgok Hospital, Daegu, Korea
3Department of Medical & Biological Engineering, Kyungpook National University, Daegu, Korea
4Department of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
5Department of Radiology, Kyungpook National University Hospital, Daegu, Korea
6Coreline Soft Co., Ltd., Seoul, Korea
7GE HealthCare, Munich, Germany
8Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, United States
9Department of Psychiatry, Kyungpook National University Hospital, Daegu, Korea
∗These authors equally contributed to the work.
Corresponding authors: Changho Choi, Ph.D., Seung Jae Lee, M.D., Ph.D.
Abstract
Background: Glutathione (GSH) is a crucial antioxidant in the human brain. Although proton magnetic resonance spectroscopy (MRS) using the MEscher-GArwood Point RESolved Spectroscopy (MEGA-PRESS) sequence is highly recommended, limited literature has measured cortical GSH using this method in major psychiatric disorders.
Methods: By combining MRS using the MEGA-PRESS and resting-state functional magnetic resonance imaging, we quantified brain GSH and glutamate in the medial prefrontal cortex (mPFC) and precuneus and explore relationships between the GSH levels and intrinsic neuronal activity as well as clinical symptoms among the three groups of healthy controls (HCs, N=30), major depressive disorder (MDD, N=28), and obsessive-compulsive disorder (OCD, N=28).
Results: GSH concentrations were lower in both the mPFC and precuneus in both the MDD and OCD groups compared to HCs. In HCs, positive correlations were noted between the GSH and glutamate levels, and between GSH and fractional amplitude of low-frequency fluctuations (fALFF) in both regions. However, while these correlations were absent in both patient groups, they showed a weak positive correlation between glutamate and fALFF values. Moreover, GSH levels negatively correlated with depressive and compulsive symptoms in MDD and OCD, respectively.
Conclusions: These findings suggest that reduced GSH levels and an imbalance between GSH and glutamate could increase oxidative stress and alter neurotransmitter signaling, leading to disruptions in GSH-related neurochemical-neuronal coupling and psychopathologies across MDD and OCD. Understanding these mechanisms could provide valuable insights into the underlying processes of these disorders, potentially becoming a springboard for future directions and advancing our knowledge of their neurobiological foundations.
논문정보
- Research article
- 2024년 08월 (BRIC 등록일 2024-09-20)
- 국내(교신)+국외 연구진
- 의약학 > 응용의학
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