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Adv. Healthc. Mater., Sep 02 2024, | https://doi.org/10.1002/adhm.202401927
Recapitulating the Cancer-Immunity Cycle on a Chip
Yujin Lee 1, Jaehong Min 2, Solbin Kim 1, Wooju Park 2, Jihoon Ko 2, Noo Li Jeon 1,3,4,5
1Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, 08826, Republic of Korea.
2Department of BioNano Technology, Gachon University, Seongnam-si, Gyeonggi-do, 13120, Republic of Korea.
3Department of Mechanical Engineering, Seoul National University, Seoul, 08826, Republic of Korea.
4Institute of Advanced Machines and Design, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
5Qureator, Inc., San Diego, CA, 92110, USA.
Y.L. and J.M. contributed equally to this work.
Corresponding Authors: Jihoon Ko, Noo Li Jeon
Abstract
The cancer-immunity cycle is a fundamental framework for understanding how the immune system interacts with cancer cells, balancing T cell recognition and elimination of tumors while avoiding autoimmune reactions. Despite advancements in immunotherapy, there remains a critical need to dissect each phase of the cycle, particularly the interactions among the tumor, vasculature, and immune system within the tumor microenvironment (TME). Innovative platforms such as organ-on-a-chip, organoids, and bioprinting within microphysiological systems (MPS) are increasingly utilized to enhance the understanding of these interactions. These systems meticulously replicate crucial aspects of the TME and immune responses, providing robust platforms to study cancer progression, immune evasion, and therapeutic interventions with greater physiological relevance. This review explores the latest advancements in MPS technologies for modeling various stages of the cancer-immune cycle, critically evaluating their applications and limitations in advancing the understanding of cancer-immune dynamics and guiding the development of next-generation immunotherapeutic strategies.
논문정보
- Review Paper
- 2024년 09월 (BRIC 등록일 2024-09-12)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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