한빛사논문
- 조회292
Sang Yean Kim 1,2,3,5, Min Jeong Na 1,2,3,5, Sungpil Yoon 1,2,3, Eunbi Shin 1,2,4, Jin Woong Ha 1,2,4, Soyoung Jeon 1,2,4 and Suk Woo Nam 1,2,3,4,*
1Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
2Functional RNomics Research Center, The Catholic University of Korea, Seoul, Republic of Korea.
3NEORNAT Inc., Seoul, Republic of Korea.
4Department of Biomedicine & Health Sciences, Graduate School, The Catholic University of Korea, Seoul, Korea.
5These authors contributed equally: Sang Yean Kim, Min Jeong Na.
*Corresponding author: correspondence to Suk Woo Nam
Abstract
Functional variations in coding and noncoding RNAs are crucial in tumorigenesis, with cancer-specific alterations often resulting from chemical modifications and posttranscriptional processes mediated by enzymes. These RNA variations have been linked to tumor cell proliferation, growth, metastasis, and drug resistance and are valuable for identifying diagnostic or prognostic cancer biomarkers. The diversity of posttranscriptional RNA modifications, such as splicing, polyadenylation, methylation, and editing, is particularly significant due to their prevalence and impact on cancer progression. Additionally, other modifications, including RNA acetylation, circularization, miRNA isomerization, and pseudouridination, are recognized as key contributors to cancer development. Understanding the mechanisms underlying these RNA modifications in cancer can enhance our knowledge of cancer biology and facilitate the development of innovative therapeutic strategies. Targeting these RNA modifications and their regulatory enzymes may pave the way for novel RNA-based therapies, enabling tailored interventions for specific cancer subtypes. This review provides a comprehensive overview of the roles and mechanisms of various coding and noncoding RNA modifications in cancer progression and highlights recent advancements in RNA-based therapeutic applications.
논문정보
- Review Paper
- 2024년 09월 (BRIC 등록일 2024-09-03)
- 국내 연구진
- 생명과학 > 세포생물학
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