김정석 (한양대학교 약학대학)

한빛사논문

조회42

김정석Jung Suk Kim

한양대학교 약학대학

J. Control. Release, Aug 30 2024, 374 S0168-3659(24)00584-4 | https://doi.org/10.1016/j.jconrel.2024.08.034 Injectable dual thermoreversible hydrogel for sustained intramuscular drug delivery

Fakhar Ud Din ^a,b,1, Jung Suk Kim^a,1, Ho Cheol Lee ^a, Seunghyun Cheon ^a, Mi Ran Woo ^a, Sanghyun Woo ^a, Sae Kwang Ku^c, Hye Hyun Yoo^a, Jong Oh. Kim^d, Sung Giu Jin^e, Han-Gon Choi^a*

^aCollege of Pharmacy, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan 15588, South Korea

^bDepartment of Pharmacy, Quaid-I-Azam University, Islamabad 45320, Pakistan

^cCollege of Oriental Medicine, Daegu Haany University, Gyongsan 712-715, South Korea

^dCollege of Pharmacy, Yeungnam University, 214-1, Dae-Dong, Gyongsan 712-749, South Korea

^eDepartment of Pharmaceutical Engineering, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan 31116, South Korea

¹These authors contributed equally to this work.

^*Corresponding authors: Han-Gon Choi

Abstract

Herein, we reported novel docetaxel-decorated solid lipid nanoparticle (DCT-SLN)-loaded dual thermoreversible system (DCT-DRTS) for intramuscular administration with reduced burst effect, sustained release and improved antitumor efficacy. The optimized DCT-DRTs was subjected to in-vitro and in-vivo analyses. Antitumor evaluation of the DCT-DRTS was executed and compared with DCT-hydrogel, and DCT-suspension trailed by the histopathological and immune-histochemical analyses. The DCT-SLN gave a mean particle size of 157 nm and entrapment efficiency of 93 %. It was a solid at room temperature, and changed to liquid at physiological temperature due to its melting point of about 32 °C. Unlikely, poloxamer mixture remained liquefied at 25-27 °C, however converted to gel at physiological temperature. This behavior demonstrated opposed reversible property of the DCT-SLN and poloxamer hydrogel in DCT-DRTS system, making it ideal for intramuscular administration and quick gelation inside the body. The DCT-DRTS sustained the drugs release and unlike DCT-hydrogel, the preliminary plasma concentration of DCT-DRTS was significantly reduced, overcoming the burst release. A meaningfully enhanced antitumor efficacy and improved survival rate was observed from DCT-DRTS in tumor cell xenograft athymic nude mice. Additionally, increased apoptotic and reduced proliferation markers were observed in DCT-DRTS treated tumor masses. It was concluded that DCT-DRTS may be a suitable choice for intramuscular administration of DCT with sustained release, improved bioavailability, reduced toxicity and enhanced antitumor effects.

논문정보

형식Research article
게재일2024년 08월 (BRIC 등록일 2024-09-11)
연구진국내(교신)+국외 연구진
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