Binod Timalsina (기초과학연구원)

한빛사논문

조회107

기초과학연구원

Nat. Rev. Neurosci., 22 August 2024 | https://doi.org/10.1038/s41583-024-00851-9 Advances in the labelling and selective manipulation of synapses

Binod Timalsina ¹, Sangkyu Lee ¹ & Bong-Kiun Kaang^{1 *}

¹Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, South Korea

^*Corresponding author: correspondence to Bong-Kiun Kaang

Abstract

Synapses are highly specialized neuronal structures that are essential for neurotransmission, and they are dynamically regulated throughout the lifetime. Although accumulating evidence indicates that these structures are crucial for information processing and storage in the brain, their precise roles beyond neurotransmission are yet to be fully appreciated. Genetically encoded fluorescent tools have deepened our understanding of synaptic structure and function, but developing an ideal methodology to selectively visualize, label and manipulate synapses remains challenging. Here, we provide an overview of currently available synapse labelling techniques and describe their extension to enable synapse manipulation. We categorize these approaches on the basis of their conceptual bases and target molecules, compare their advantages and limitations and propose potential modifications to improve their effectiveness. These methods have broad utility, particularly for investigating mechanisms of synaptic function and synaptopathy.

논문정보

형식Review Paper
게재일2024년 08월 (BRIC 등록일 2024-08-23)
연구진국내 연구진
분야 생명과학 > 신경생물학

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