한빛사논문
- 조회282
Kyerl Park 1,2, Yoonsoo Yeo 1,2, Kisung Shin 2 & Jeehyun Kwag 1 *
1Department of Brain and Cognitive Sciences, Seoul National University, Seoul 08826, Republic of Korea.
2Department of Brain and Cognitive Engineering, Korea University, Seoul 02841, Republic of Korea.
*Corresponding author: correspondence to Jeehyun Kwag
Abstract
Egocentric neural representations of environmental features, such as edges and vertices, are important for constructing a geometrically detailed egocentric cognitive map for goal-directed navigation and episodic memory. While egocentric neural representations of edges like egocentric boundary/border cells exist, those that selectively represent vertices egocentrically are yet unknown. Here we report that granular retrosplenial cortex (RSC) neurons in male mice generate spatial receptive fields exclusively near the vertices of environmental geometries during free exploration, termed vertex cells. Their spatial receptive fields occurred at a specific orientation and distance relative to the heading direction of mice, indicating egocentric vector coding of vertex. Removing physical boundaries defining the environmental geometry abolished the egocentric vector coding of vertex, and goal-directed navigation strengthened the egocentric vector coding at the goal-located vertex. Our findings suggest that egocentric vector coding of vertex by granular RSC neurons helps construct an egocentric cognitive map that guides goal-directed navigation.
논문정보
- Research article
- 2024년 08월 (BRIC 등록일 2024-08-22)
- 국내 연구진
- 바이오·의료융합 > 뇌인지과학
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