한빛사논문
- 조회415
University of California Irvine School of Medicine (현 New York University)
Heechul Jun 1,6, Jason Y. Lee 1,6, Nicholas R. Bleza 1, Ayana Ichii 1, Jordan D. Donohue 1 & Kei M. Igarashi 1,2,3,4,5 ,*
1Department of Anatomy and Neurobiology, School of Medicine, University of California Irvine, Irvine, CA, USA.
2Department of Biomedical Engineering, Samueli School of Engineering, University of California Irvine, Irvine, CA, USA.
3Center for Neural Circuit Mapping, School of Medicine, University of California Irvine, Irvine, CA, USA.
4Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, CA, USA.
5Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA.
6These authors contributed equally: Heechul Jun, Jason Y. Lee.
*Corresponding author: correspondence to Kei M. Igarashi
Abstract
The ability to learn novel items depends on brain functions that store information about items classified by their associated meanings and outcomes, but the underlying neural circuit mechanisms of this process remain poorly understood. Here we show that deep layers of the lateral entorhinal cortex (LEC) contain two groups of ‘item–outcome neurons’: one developing activity for rewarded items during learning, and another for punished items. As mice learned an olfactory item–outcome association, we found that the neuronal population of LEC layers 5/6 (LECL5/6) formed an internal map of pre-learned and novel items, classified into dichotomic rewarded versus punished groups. Neurons in the medial prefrontal cortex (mPFC), which form a bidirectional loop circuit with LECL5/6, developed an equivalent item–outcome rule map during learning. When LECL5/6 neurons were optogenetically inhibited, tangled mPFC representations of novel items failed to split into rewarded versus punished groups, impairing new learning by mice. Conversely, when mPFC neurons were inhibited, LECL5/6 representations of individual items were held completely separate, disrupting both learning and retrieval of associations. These results suggest that LECL5/6 neurons and mPFC neurons co-dependently encode item memory as a map of associated outcome rules.
논문정보
- Research article
- 2024년 08월 (BRIC 등록일 2024-08-26)
- 국외 연구진
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
