한빛사논문
- 조회62
인하대학교 의과대학
Young Eun Chon1, Young-Joo Jin2, Jihyun An3, Hee Yeon Kim4, Miyoung Choi5, Dae Won Jun6, Mi Na Kim7,8, Ji Won Han9, Han Ah Lee10, Jung Hwan Yu2, Seung Up Kim7,8
1Department of Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea
2Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Republic of Korea
3Department of Gastroenterology and Hepatology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Republic of Korea
4Department of Internal Medicine, College of Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea
5Division of Health Technology Assessment Research, National Evidence-Based Healthcare Collaborating Agency (NECA), Seoul, Korea
6Department of Internal Medicine, Hanyang University Hospital, Hanyang University College of Medicine, Seoul, Republic of Korea
7Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
8Yonsei Liver Center, Severance Hospital, Seoul, Republic of Korea
9Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea
10Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea
*Young Eun Chon and Young-Joo Jin contributed equally to this work.
Correspondence : Jung Hwan Yu, Seung Up Kim
Abstract
Background/aims
Opinions differ regarding transient elastography and magnetic resonance elastography (TE/MRE) cut-offs for diagnosing advanced fibrosis (AF) in patients with non-alcoholic fatty liver disease (NAFLD). We investigated the diagnostic performance and optimal cut-off values of TE and MRE for diagnosing AF.
Methods
Literature databases, including Medline, EMBASE, Cochrane Library, and KoreaMed, were used to identify relevant studies published up to June 13, 2023. We selected studies evaluating TE and MRE regarding the degree of liver fibrosis using liver biopsy as the reference. The sensitivity, specificity, and area under receiver operating characteristics curves (AUCs) of the pooled data for TE and MRE for each fibrosis stage and optimal cut-offs for AF were investigated.
Results
A total of 19,199 patients from 63 studies using TE showed diagnostic AUC of 0.83(95% confidence interval: 0.80–0.86), 0.83(0.80–0.86), 0.87(0.84–0.90), and 0.94(0.91–0.96) for ≥F1, ≥F2, ≥F3, and F4 stages, respectively. Similarly, 1,484 patients from 14 studies using MRE showed diagnostic AUC of 0.89(0.86–0.92), 0.92(0.89–0.94), 0.89(0.86–0.92), and 0.94(0.91–0.96) for ≥F1, ≥F2, ≥F3, and F4 stages respectively. The diagnostic AUC for AF using TE was highest at 0.90 with a cut-off of 7.1–7.9 kPa, and that of MRE was highest at 0.94 with a cut-off of 3.62–3.8 kPa.
Conclusions
TE(7.1–7.9 kPa) and MRE(3.62–3.8 kPa) with the suggested cut-offs showed favorable accuracy for diagnosing AF in patients with NAFLD. This result will serve as a basis for clinical guidelines for non-invasive tests and differential diagnosis of AF.
논문정보
- Research article
- 2024년 08월 (BRIC 등록일 2024-08-28)
- 국내 연구진
- 의약학 > 종양의학
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
연구자 ID
관련분야 연구자보기
관련분야 논문보기
