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Trends Immunol., Aug 19 2024, S1471-4906(24)00184-4 | https://doi.org/10.1016/j.it.2024.07.009
The extracellular matrix in solid tumor immunotherapy
Yongbum Cho 1, Junsang Doh 2
1Research Institute of Advanced Materials (RIAM), Seoul National University, Seoul, South Korea.
2Research Institute of Advanced Materials (RIAM), Seoul National University, Seoul, South Korea; Department of Materials Science and Engineering, Institute of Engineering Research, BioMAX, Soft Foundry Institute, Seoul National University, Seoul, South Korea.
Contact : Junsang Doh
Abstract
The extracellular matrix (ECM) of solid tumors impacts the antitumor activities of CD8+ T and natural killer (NK) cells in a variety of ways. Cell motility is restricted by the tumor ECM which creates physical barriers. The tumor ECM directly alter the phenotypes and functions of cytotoxic lymphocytes, and indirectly influences immunological synapse-mediated interactions between cytotoxic lymphocytes and cancer cells. Therefore, strategies to improve solid tumor immunotherapy should be established by considering complex ternary interactions between cytotoxic lymphocytes, cancer cells, and the tumor ECM. Novel bioengineering tools approximating key characteristics of the tumor ECM, such as in vitro reconstituted 3D ECMs and microfluidics are valuable from a fundamental study viewpoint and from a translational perspective, aiming to enable systematic screening approaches.
논문정보
- Review Paper
- 2024년 08월 (BRIC 등록일 2024-08-22)
- 국내 연구진
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