이아인 (서울대학교 의과대학)

한빛사논문

조회112

서울대학교 의과대학

Immunol. Rev., Aug 19 2024, | https://doi.org/10.1111/imr.13382 DNA sensors in metabolic and cardiovascular diseases: Molecular mechanisms and therapeutic prospects

Hyosang Kwak ¹, Ein Lee ², Rajendra Kark^{i 1,3}

¹Department of Biological Sciences, College of Natural Science, Seoul National University, Seoul, South Korea.

²Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, South Korea.

³Nexus Institute of Research and Innovation (NIRI), Kathmandu, Nepal.

Hyosang Kwak and Ein Lee contributed equally to this study.

Corresponding Author: Rajendra Karki

Abstract

DNA sensors generally initiate innate immune responses through the production of type I interferons. While extensively studied for host defense against invading pathogens, emerging evidence highlights the involvement of DNA sensors in metabolic and cardiovascular diseases. Elevated levels of modified, damaged, or ectopically localized self-DNA and non-self-DNA have been observed in patients and animal models with obesity, diabetes, fatty liver disease, and cardiovascular disease. The accumulation of cytosolic DNA aberrantly activates DNA signaling pathways, driving the pathological progression of these disorders. This review highlights the roles of specific DNA sensors, such as cyclic AMP-GMP synthase and stimulator of interferon genes (cGAS-STING), absent in melanoma 2 (AIM2), toll-like receptor 9 (TLR9), interferon gamma-inducible protein 16 (IFI16), DNA-dependent protein kinase (DNA-PK), and DEAD-box helicase 41 (DDX41) in various metabolic disorders. We explore how DNA signaling pathways in both immune and non-immune cells contribute to the development of these diseases. Furthermore, we discuss the intricate interplay between metabolic stress and immune responses, offering insights into potential therapeutic targets for managing metabolic and cardiovascular disorders. Understanding the mechanisms of DNA sensor signaling in these contexts provides a foundation for developing novel interventions aimed at mitigating the impact of these pervasive health issues.

논문정보

형식Review Paper
게재일2024년 08월 (BRIC 등록일 2024-08-20)
연구진국내(교신)+국외 연구진
분야 생명과학 > 면역학

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