주소연 (KAIST) | 한빛사논문 > 한빛사

한빛사논문

조회370

KAIST

Adv. Sci., Aug 19 2024, | https://doi.org/10.1002/advs.202406678 Lateral Piezoelectricity of Alzheimer's Aβ Aggregates

Jinhyeong Jang ^{1 2 †}, Soyun Joo ^{1 †}, Jiwon Yeom ¹, Yonghan Jo¹, Jingshu Zhang ¹, Seungbum Hong ^{1 *}, Chan Beum Park^{1 *}

¹Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Daejeon, 34141, Republic of Korea.

²Applied Science Research Institute, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Daejeon, 34141, Republic of Korea.

^†J.J. and S.J. contributed equally to this work.
^*Corresponding authors: correspondence to Seungbum Hong or Chan Beum Park

Abstract

Alzheimer's disease (AD) is the most frequent neurodegenerative disorder in the elderly aged over 65. The extracellular accumulation of beta-amyloid (Aβ) aggregates in the brain is considered as the major event worsening the AD symptoms, but its underlying reason has remained unclear. Here the piezoelectric characteristics of Aβ aggregates are revealed. The vector piezoresponse force microscopy (PFM) analysis results exhibit that Aβ fibrils have spiraling piezoelectric domains along the length and a lateral piezoelectric constant of 44.1 pC N^-1. Also, the continuous sideband Kelvin probe force microscopy (KPFM) images display that the increment of charge-induced surface potential on a single Aβ fibril is allowed to reach above +1700 mV in response to applied forces. These findings shed light on the peculiar mechano-electrical surface properties of pathological Aβ fibrils that exceed those of normal body components.

논문정보

형식Research article
게재일2024년 08월 (BRIC 등록일 2024-08-20)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

댓글 작성 로그인

CV 열람하기

연락처 보기