최원민 (Harvard Medical School)

한빛사논문

조회119

Harvard Medical School

CV File 145 kb

ACS Nano, Aug 14 2024, | https://doi.org/10.1021/acsnano.4c06888 Hybrid Nanoparticle-Hydrogel Systems for Drug Delivery Depots and Other Biomedical Applications

Wonmin Choi ¹, Daniel S Kohane^1*

¹Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, United States.

^*Corresponding AuthorDaniel S. Kohane

Abstract

Hydrogel-based depots typically tend to remain where injected and have excellent biocompatibility but are relatively poor at controlling drug release. Nanoparticles (NPs) typically have the opposite properties. The smaller the NPs are, the more likely they are to leave the site of injection. Their biocompatibility is variable depending on the material but can be poor. However, NPs can be good at controlling drug release. In these and other properties, combining NPs and hydrogels can leverage their advantages and negate their disadvantages. This review highlights the rationale for hybrid NP-hydrogel systems in drug delivery, the basic methods of producing them, and examples where combining the two systems addressed specific problems.

논문정보

형식Review Paper
게재일2024년 08월 (BRIC 등록일 2024-08-28)
연구진국외 연구진
분야 바이오·의료융합 > 바이오소재

댓글 작성 로그인

CV 열람하기

연락처 보기