김세용 (충남대학교)

한빛사논문

조회67

김세용Sea-Yong Kim

충남대학교

J. Hazard. Mater., Aug 11 2024, 478 S0304-3894(24)02065-X | https://doi.org/10.1016/j.jhazmat.2024.135486 First investigation of the temporal distribution of neurotoxin β-N-methylamino-L-alanine (BMAA) and the candidate causative microalgae along the South Sea Coast of Korea

Sea-Yong Kim ^a, Mungi Kim ^b, Young Kyun Lim^c, Seung Ho Baek ^c, Ji Yoon Kim ^d, Kwang-Guk An ^d, Seongjin Hong ^a,b

^aDepartment of Marine Environmental Sciences & Institute of Marine Environmental Sciences, Chungnam National University, Daejeon 34134, Republic of Korea

^bDepartment of Earth, Environmental & Space Sciences, Chungnam National University, Daejeon 34134, Republic of Korea

^cEcological Risk Research Department, Korea Institute of Ocean Science and Technology, Geoje 53201, Republic of Korea

^dDepartment of Bioscience and Biotechnology, Chungnam National University, Daejeon 34134, Republic of Korea

Correspondence to: Seongjin Hong

Abstract

The neurotoxin β-N-methylamino-L-alanine (BMAA), produced by cyanobacteria and diatoms, has been implicated as an environmental risk factor for neurodegenerative diseases. This study first investigated the occurrence and monthly distributions of BMAA and its isomers, 2,4-diaminobutyric acid (DAB) and N-2-aminoethylglycine (AEG), in phytoplankton and mussels from 11 sites along the South Sea Coast of Korea throughout 2021. These toxins were quantified using LC-MS/MS, revealing elevated BMAA concentrations from late autumn to spring, with phase lags observed between phytoplankton and mussels. The highest concentration of BMAA in phytoplankton was detected in November (mean: 1490 ng g^-1 dry weight (dw)), while in mussels, it peaked in December (mean: 1240 ng g^-1 dw). DAB was detected in phytoplankton but was absent in mussels, indicating limited bioaccumulation potential. In February, the peak mean DAB concentration in phytoplankton was 89 ng g^-1 dw. AEG was not detected in any samples. Chlorophyll-a concentrations consistently showed an inverse correlation with BMAA concentrations in mussels throughout the year. Through correlation analysis, four diatom genera, Bacillaria, Hemiaulus, Odontella, and Pleurosigma, were identified as potential causative microalgae of BMAA. This study offers insights into identifying the causative microalgae for BMAA and informs future regulatory efforts regarding unmanaged biotoxins.

논문정보

형식Research article
게재일2024년 08월 (BRIC 등록일 2024-08-28)
연구진국내 연구진
분야 생명과학 > 분류/생태/환경생물학

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