한빛사논문
- 조회102
Jung-Hwan Lee a,b,c,d,e,f,1, Seong-Jin Shin a,e,1, Jun Hee Lee a,c,d,e, Jonathan C. Knowles a,e,f,g, Hae-Hyoung Lee a,b,c,e,f, Hae-Won Kim a,b,c,d,e,f
aInstitute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea
bDepartment of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 31116, Republic of Korea
cDepartment of Nanobiomedical Science and BK21 NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Republic of Korea
dCell & Matter Institute, Dankook University, Cheonan 31116, Republic of Korea
eMechanobiology Dental Medicine Research Center, Dankook University, Cheonan 31116, Republic of Korea
fUCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan 31116, Republic of Korea
gUCL Eastman Dental Institute, University College London, London NW3 2PX, United Kingdom
1These authors contributed equally to this work.
Corresponding authors: Jung-Hwan Lee, Hae-Won Kim
Abstract
Recent cumulative findings signify the adaptive immunity of materials as a key agenda in tissue healing that can improve regenerative events and outcomes. Modulating immune responses, mainly the recruitment and functions of T and B cells and their further interplay with innate immune cells (e.g., dendritic cells, macrophages) can be orchestrated by materials. For instance, decellularized matrices have been shown to promote muscle healing by inducing T helper 2 (Th2) cell immunity, while synthetic biopolymers exhibit differential effects on B cell responses and fibrosis compared decellularized matrices. We discuss the recent findings on how implantable materials instruct the adaptive immune events and the subsequent tissue healing process. In particular, we dissect the materials’ physicochemical properties (shape, size, topology, degradation, rigidity, and matrix dynamic mechanics) to demonstrate the relations of these parameters with the adaptive immune responses in vitro and the underlying biological mechanisms. Furthermore, we present evidence of recent in vivo phenomena, including tissue healing, cancer progression, and fibrosis, wherein biomaterials potentially shape adaptive immune cell functions and in vivo outcomes. Our discussion will help understand the materials-regulated immunology events more deeply, and offer the design rationale of materials with tunable matrix properties for accelerated tissue repair and regeneration.
논문정보
- Review Paper
- 2024년 08월 (BRIC 등록일 2024-08-16)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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