한성수 (영남대학교)

한빛사논문

조회118

영남대학교

Ageing Res. Rev., Aug 10 2024, S1568-1637(24)00268-X | https://doi.org/10.1016/j.arr.2024.102450 Advancing the Understanding of Diabetic Encephalopathy through Unravelling Pathogenesis and Exploring Future Treatment Perspectives

Aarti Nagayach ^a,1, Rakesh Bhaskar ^b,1, Shampa Ghosh ^d, Krishna Kumar Singh ^e, Sung Soo Han ^b,c, Jitendra Kumar Sinha ^d

^aDepartment of Cancer Biology, College of Medicine, University of Cincinnati, Cincinnati, OH, 45267, USA

^bSchool of Chemical Engineering, Yeungnam University, Gyeongsan 38541, South Korea

^cResearch Institute of Cell Culture, Yeungnam University, Gyeongsan 38541, South Korea

^dGloNeuro, Sector 107, Vishwakarma Road, Noida, Uttar Pradesh 201301 India

^eSymbiosis Centre for Information Technology, Symbiosis International (Deemed University), Rajiv Gandhi InfoTech Park, Hinjawadi, Pune, Maharashtra 411057 India

¹Equal first author

Correspondence to: Sung Soo Han, Jitendra Kumar Sinha

Abstract

Diabetic encephalopathy (DE), a significant micro-complication of diabetes, manifests as neurochemical, structural, behavioral, and cognitive alterations. This condition is especially dangerous for the elderly because aging raises the risk of neurodegenerative disorders and cognitive impairment, both of which can be made worse by diabetes. Despite its severity, diagnosis of this disease is challenging, and there is a paucity of information on its pathogenesis. The pivotal roles of various cellular pathways, activated or influenced by hyperglycemia, insulin sensitivity, amyloid accumulation, tau hyperphosphorylation, brain vasculopathy, neuroinflammation, and oxidative stress, are widely recognized for contributing to the potential causes of diabetic encephalopathy. We also reviewed current pharmacological strategies for DE encompassing a comprehensive approach targeting metabolic dysregulations and neurological manifestations. Antioxidant-based therapies hold promise in mitigating oxidative stress-induced neuronal damage, while anti-diabetic drugs offer neuroprotective effects through diverse mechanisms, including modulation of insulin signaling pathways and neuroinflammation. Additionally, tissue engineering and nanomedicine-based approaches present innovative strategies for targeted drug delivery and regenerative therapies for DE. Despite significant progress, challenges remain in translating these therapeutic interventions into clinical practice, including long-term safety, scalability, and regulatory approval. Further research is warranted to optimize these approaches and address remaining gaps in the management of DE and associated neurodegenerative disorders.

논문정보

형식Review Paper
게재일2024년 08월 (BRIC 등록일 2024-08-21)
연구진국내(교신)+국외 연구진
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