한빛사논문
- 조회148
University of California, San Francisco, San Francisco Veterans Affairs Medical Center
Parna Saha 1,2, Rebecca E. Andersen 1,2,6, Sung Jun Hong 1,2, Eugene Gil 1,2, Jeffrey Simms 3, Hyeonseok Choi 4 & Daniel A. Lim 1,2,5,*
1Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
2Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
3Behavioral Core, Gladstone Institutes, San Francisco, CA 94158, USA.
4Department of Molecular and Cell Biology Undergraduate Program, University of California, Berkeley, Berkeley, CA 94720, USA.
5San Francisco Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, CA 94143, USA.
6Present address: Division of Genetics and Genomics, Harvard Medical School, Boston Children’s Hospital, Boston, MA 02115, USA.
*Corresponding author: correspondence to Daniel A. Lim
Abstract
The aberrant expression of specific long noncoding RNAs (lncRNAs) has been associated with cognitive and psychiatric disorders. Although a growing number of lncRNAs are now known to regulate neural cell development and function, relatively few lncRNAs have been shown to underlie animal behavior. Pnky is an evolutionarily conserved, neural lncRNA that regulates brain development. Using mouse genetic strategies, we show that Pnky has sex-specific roles in mouse behavior and that this lncRNA can underlie specific behavior by functioning in trans. Male Pnky-knockout mice have decreased context generalization in a paradigm of associative fear learning and memory. In female Pnky-knockout mice, there is an increase in the acoustic startle response, a behavior that is altered in affective disorders. Remarkably, expression of Pnky from a bacterial artificial chromosome transgene decreases the acoustic startle response in female Pnky-knockout mice, demonstrating that Pnky can modulate specific animal behavior by functioning in trans. More broadly, these studies illustrate how specific lncRNAs can underlie cognitive and mood disorders.
논문정보
- Research article
- 2024년 08월 (BRIC 등록일 2024-08-26)
- 국외 연구진
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