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Nano Lett., Aug 09 2024, | https://doi.org/10.1021/acs.nanolett.4c03228
Polyphenol-Enabled 2D Nanopatch for Enhanced Nasal Mucoadhesion and Immune Activation
Jeong Pil Han 1, Yu Ri Nam 2, Hye Yoon Chung 1, Haeshin Lee 2, Su Cheong Yeom 1
1Graduate School of International Agricultural Technology and Institute of Green Bio Science and Technology, Seoul National University, Pyeongchang, Gangwon 25354, Republic of Korea.
2Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
J.P.H. and Y.R.N. contributed equally to this work.
Corresponding Authors : Haeshin Lee, Su Cheong Yeom
Abstract
The advancement of effective nasal mucoadhesive delivery faces challenges due to rapid mucociliary clearance (MCC). Conventional studies have employed mucoadhesive materials, mainly forming spherical nanoparticles, but these offer limited adhesion to the nasal mucosa. This study hypothesizes that a 2D nanoscale structure utilizing adhesive polyphenols can provide a superior strategy for countering MCC, aligning with the planar mucosal layers. We explore the use of tannic acid (TA), a polyphenolic molecule known for its adhesive properties and ability to form complexes with biomolecules. Our study introduces an unprecedented 2D nanopatch, assembled through the interaction of TA with green fluorescent protein (GFP), and cell-penetrating peptide (CPP). This 2D nanopatch demonstrates robust adhesion to nasal mucosa and significantly enhances immunoglobulin A secretions, suggesting its potential for enhancing nasal vaccine delivery. The promise of a polyphenol-enabled adhesive 2D nanopatch signifies a pivotal shift from conventional spherical nanoparticles, opening new pathways for delivery strategies through respiratory mucoadhesion.
논문정보
- Research article
- 2024년 08월 (BRIC 등록일 2024-08-12)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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