홍수종 (울산대학교 의과대학, 서울아산병원)

한빛사논문

조회102

울산대학교 의과대학, 서울아산병원

CV File 424 kb

J. Hazard. Mater., Jul 27 2024, 478 S0304-3894(24)01938-1 | https://doi.org/10.1016/j.jhazmat.2024.135359 Polyhexamethylene guanidine aerosol causes irreversible changes in blood proteins that associated with the severity of lung injury

Hee-Sung Ahn ^a,1, So-Yeon Lee ^b,1, Mi-Jin Kang ^c, Sang Bum Hong ^d, Jin Woo Song ^d, Kyung Hyun Do ^e, Jeounghun Yeom ^f, Jiyoung Yu ^a, Yumi Oh^g, Jeong Yeon Hong ^g, Eun Hee Chung ^h, Kyunggon Kim ^a,g,2, Soo-Jong Hong ^b,2

^aConvergence Medicine Research Center, Asan Institute for Life Sciences, Seoul, South Korea

^bDepartment of Pediatrics, Childhood Asthma Atopy Center, Humidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

^cHumidifier Disinfectant Health Center, Asan Medical Center, Seoul, South Korea

^dDepartment of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea

^eDepartment of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea

^fPrometabio Research Institute, prometabio co., ltd., Gyeonggi-do, South Korea

^gDepartment of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea

^hDepartment of Pediatrics, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, South Korea

¹These two authors contributed equally to this work.

²These two authors contributed equally to this work.

Corresponding authors: Kyunggon Kim, Soo-Jong Hong

Abstract

Polyhexamethylene guanidine (PHMG) is a positively charged polymer used as a disinfectant that kills microbes but can cause pulmonary fibrosis if inhaled. After the long-term risks were confirmed in South Korea, it became crucial to measure toxicity through diverse surrogate biomarkers, not only proteins, especially after these hazardous chemicals had cleared from the body. These biomarkers, identified by their biological functions rather than simple numerical calculations, effectively explained the imbalance of pulmonary surfactant caused by fibrosis from PHMG exposure. These long-term studies on children exposed to PHMG has shown that blood protein indicators, primarily related to apolipoproteins and extracellular matrix, can distinguish the degree of exposure to humidifier disinfectants (HDs). We defined the extreme gradient boosting models and computed reflection scores based on just ten selected proteins, which were also verified in adult women exposed to HD. The reflection scores successfully discriminated between the HD-exposed and unexposed groups in both children and adult females (AUROC: 0.957 and 0.974, respectively) and had a strong negative correlation with lung function indicators. Even after an average of more than 10 years, blood is still considered a meaningful specimen for assessing the impact of environmental exposure to toxic substances, with proteins providing in identifying the pathological severity of such conditions.

논문정보

형식Research article
게재일2024년 07월 (BRIC 등록일 2024-08-12)
연구진국내 연구진
분야 의약학 > 면역의학

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