여운홍 (Georgia Tech)

한빛사논문

조회279

Georgia Tech

CV File 383 kb

Nat. Commun., Aug 09 2024, 15 (1) 6803 | https://doi.org/10.1038/s41467-024-51300-1 All-in-one wearable drug efficacy assessment systems for bulbar muscle function using amyotrophic lateral sclerosis animal models

Beomjune Shin ^1,2,8, Youngjin Kwon ^1,3,8, Michelle Mittaz⁴, Hojoong Kim ^1,2, Xiaoxing Xu ⁴, Eugene Kim^1,2, Yoon Jae Lee ^1,5, Jimin Lee ^1,2, Woon-Hong Yeo ^1,2,6,7,* & Hyojung J. Choo ^4,*

¹Wearable Intelligent Systems and Healthcare Center (WISH Center) at the Institute for Matter and Systems, Georgia Institute of Technology, Atlanta, GA 30332, USA.
²George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
³School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
⁴Department of Cell Biology, School of Medicine, Emory University, Atlanta, GA 30322, USA.
⁵School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
⁶Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332, USA.
⁷Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
⁸These authors contributed equally: Beomjune Shin, Youngjin Kwon.

^*Corresponding authors: correspondence to Woon-Hong Yeo or Hyojung J. Choo

Abstract

Preclinical studies are crucial for developing amyotrophic lateral sclerosis drugs. Current FDA-approved drugs have been created by monitoring limb muscle function and histological analysis of amyotrophic lateral sclerosis model animals. Drug candidates for this disease have yet to be tested for bulbar-onset type due to the limitations of traditional preclinical tools: excessive animal use and discrete detection of disease progress. Here, our study introduces an all-in-one, wireless, integrated wearable system for facilitating continuous drug efficacy assessment of dysphagia-related muscles in animals during natural eating behaviors. By incorporating a kirigami-based strain-isolation mechanism, this device mounted on the skin of animals mitigates electromyography signal contamination caused by unpredictable animal movements. Our findings indicate this system, measuring the progression of motor neuron denervation, offers high precision in monitoring drug effects on dysphagia-responsible bulbar muscles. This study paves the way for more humane and efficient approaches to developing treatment solutions for degenerative neuromuscular diseases.

논문정보

형식Research article
게재일2024년 08월 (BRIC 등록일 2024-08-12)
연구진국외 연구진
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