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한빛사논문
- 조회498
Max Planck Institute for Biological Intelligence (현 Stanford University)
Nat. Commun., Aug 11 2024, 15 (1) | https://doi.org/10.1038/s41467-024-50889-7
Genetically- and spatially-defined basolateral amygdala neurons control food consumption and social interaction
Hansol Lim 1, Yue Zhang 2, Christian Peters 1, Tobias Straub 3, Johanna Luise Mayer 1 & Rüdiger Klein 1,*
1Department Molecules – Signaling – Development, Max Planck Institute for Biological Intelligence, Martinsried, Germany.
2Department Synapses – Circuits -Plasticity, Max Planck Institute for Biological Intelligence, Martinsried, Germany.
3Biomedical Center Core Facility Bioinformatics, LMU, Munich, Germany.
*Corresponding author: correspondence to Rüdiger Klein
Abstract
The basolateral amygdala (BLA) contains discrete neuronal circuits that integrate positive or negative emotional information and drive the appropriate innate and learned behaviors. Whether these circuits consist of genetically-identifiable and anatomically segregated neuron types, is poorly understood. Also, our understanding of the response patterns and behavioral spectra of genetically-identifiable BLA neurons is limited. Here, we classified 11 glutamatergic cell clusters in mouse BLA and found that several of them were anatomically segregated in lateral versus basal amygdala, and anterior versus posterior regions of the BLA. Two of these BLA subpopulations innately responded to valence-specific, whereas one responded to mixed - aversive and social - cues. Positive-valence BLA neurons promoted normal feeding, while mixed selectivity neurons promoted fear learning and social interactions. These findings enhance our understanding of cell type diversity and spatial organization of the BLA and the role of distinct BLA populations in representing valence-specific and mixed stimuli.
논문정보
- Research article
- 2024년 08월 (BRIC 등록일 2024-08-13)
- 국외 연구진
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