이효원 (한국과학기술연구원)

한빛사논문

조회162

한국과학기술연구원

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Adv. Sci., Aug 09 2024, | https://doi.org/10.1002/advs.202403245 Central Role of Hypothalamic Circuits for Acupuncture's Anti-Parkinsonian Effects

Ju-Young Oh ^{1 2} ^†, Hyowon Lee ^{1 3}^†, Sun-Young Jang ^{1 2}, Hyunjin Kim^{3 4}, Geunhong Park ³, Almas Serikov ³, Jae-Hwan Jang ², Junyeop Kim ⁵, Seulkee Yang ³, Moonsun Sa ⁶, Sung Eun Lee ⁶, Young-Eun Han ³, Tae-Yeon Hwang ^{1 2}, Sharon Jiyoon Jung ⁷, Hee Young Kim ⁸, Seung Eun Lee ^{6 9}, Soo-Jin Oh ³, Jeongjin Kim ³, Jeongyeon Kim ¹⁰, Jongpil Kim ⁵, Thomas J McHugh^{3 11}, C Justin Lee ⁶, Min-Ho Nam ^{3 4 *}, Hi-Joon Park^{1 2 4 *}

¹College of Korean Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea.

²Studies of Translational Acupuncture Research (STAR), Kyung Hee University, Seoul, 02447, Republic of Korea.

³Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.

⁴Department of KHU-KIST Convergence Science and Technology, Kyung Hee University, Seoul, 02447, Republic of Korea.

⁵Laboratory of Stem Cells & Cell Reprogramming, Department of Chemistry, Dongguk University, Seoul, 04629, Republic of Korea.

⁶Center for Cognition and Sociality, Institute for Basic Science, Daejeon, 34126, Republic of Korea.

⁷Technological Convergence Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.

⁸Department of Physiology, Yonsei University, Seoul, 03722, Republic of Korea.

⁹Research Animal Resource Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.

¹⁰Emotion, Cognition & Behavior Research Group, Korea Brain Research Institute, Daegu, 41062, Republic of Korea.

¹¹Laboratory for Circuit and Behavioral Physiology, RIKEN, Wako-shi Saitama, 351-0198, Japan.

^†J.-Y.O., and H.L. contributed equally to this work.
^*Corresponding authors: correspondence to Min-Ho Nam or Hi-Joon Park

Abstract

Despite clinical data stretching over millennia, the neurobiological basis of the effectiveness of acupuncture in treating diseases of the central nervous system has remained elusive. Here, using an established model of acupuncture treatment in Parkinson's disease (PD) model mice, we show that peripheral acupuncture stimulation activates hypothalamic melanin-concentrating hormone (MCH) neurons via nerve conduction. We further identify two separate neural pathways originating from anatomically and electrophysiologically distinct MCH neuronal subpopulations, projecting to the substantia nigra and hippocampus, respectively. Through chemogenetic manipulation specifically targeting these MCH projections, their respective roles in mediating the acupuncture-induced motor recovery and memory improvements following PD onset are demonstrated, as well as the underlying mechanisms mediating recovery from dopaminergic neurodegeneration, reactive gliosis, and impaired hippocampal synaptic plasticity. Collectively, these MCH neurons constitute not only a circuit-based explanation for the therapeutic effectiveness of traditional acupuncture, but also a potential cellular target for treating both motor and non-motor PD symptoms.

논문정보

형식Research article
게재일2024년 08월 (BRIC 등록일 2024-08-12)
연구진국내(교신)+국외 연구진
분야 의약학 > 한의학

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