Prof Yi-Long Wu MD ^a, Prof Valentina Guarneri PhD ^b, Pei Jye Voon MD ^c, Boon Khaw Lim MRCP ^d, Prof Jin-Ji Yang MD ^a, Prof Marie Wislez PhD ^e,f, Prof Cheng Huang PhD ^g, Prof Chong Kin Liam MBBS [UM] ^h, Prof Julien Mazieres PhD ⁱ, Lye Mun Tho PhD ^j, Prof Hidetoshi Hayashi PhD ^k, Nguyen Viet Nhung PhD ^l, Puey Ling Chia PhD ^m, Prof Filippo de Marinis PhD ⁿ, Jo Raskin MD ^o, Prof Qinghua Zhou MD ^p, Giovanna Finocchiaro MD ^q, Anh Tuan Le PhD ^r, Prof Jialei Wang MD ^s, Christophe Dooms PhD ^t, Terufumi Kato PhD ^u, Ernest Nadal PhD ^v, Prof How Soon Hin MD ^w, Prof Egbert F Smit PhD ^x,y, Prof Martin Wermke MD ^z, Daniel Tan PhD ^aa, Masahiro Morise PhD ^ab, Aurora O'Brate PhD ^ac, Svenja Adrian MD ^ad, Boris M Pfeiffer MD ^ag, Christopher Stroh PhD ^ah, Dilafruz Juraeva PhD ^ai, Rainer Strotmann MD ^aj, Kosalaram Goteti MD ^ak, Karin Berghoff MD ^ae, Barbara Ellers-Lenz MSc ^af, Niki Karachaliou MD ^ad, Xiuning Le MD ^al, Prof Tae Min Kim MD ^am anfor the INSIGHT ² investigators ^†

^aGuangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China

^bDepartment of Surgery, Oncology and Gastroenterology, University of Padova, Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy

^cHospital Umum Sarawak, Kuching, Sarawak, Malaysia

^dDepartment of Internal and Respiratory Medicine, Sunway Medical Centre, Selangor, Malaysia

^eService de Pneumologie, Hôpital Cochin, Assistance Publique—Hôpitaux de Paris, Paris, France

^fUniversité Paris Cité, Paris, France

^gDepartment of Thoracic Oncology, Fujian Cancer Hospital, Fuzhou, China

^hDepartment of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

ⁱCHU de Toulouse, Université Paul Sabatier, Toulouse, France

^jDepartment of Oncology, Pantai Hospital Kuala Lumpur, Kuala Lumpur, Malaysia

^kDepartment of Medical Oncology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan

^lNational Lung Hospital, University of Medicine and Pharmacy, Vietnam National University Hanoi, Viet Nam

^mDepartment of Medical Oncology, Tan Tock Seng Hospital, Singapore

ⁿDivision of Thoracic Oncology, European Institute of Oncology, IRCCS, Milan, Italy

^oDepartment of Pulmonology and Thoracic Oncology, Antwerp University Hospital (UZA), Edegem, Belgium

^pLung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China

^qIRCCS Humanitas Research Hospital, Rozzano, Milan, Italy

^rCho Ray Hospital, Ho Chi Minh City, Viet Nam

^sDepartment of Oncology, Fudan University Shanghai Cancer Center, Shanghai, China

^tDepartment of Respiratory Diseases and Respiratory Oncology Unit, University Hospitals Leuven, Leuven, Belgium

^uDepartment of Thoracic Oncology, Kanagawa Cancer Center, Yokohama, Japan

^vDepartment of Medical Oncology, Catalan Institute of Oncology IDIBELL, L'Hospitalet, Barcelona, Spain

^wHospital Tengku Ampuan Afzan, Pahang, Malaysia

^xDepartment of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands

^yDepartment of Pulmonary Diseases, Leiden University Medical Center, Leiden, Netherlands

^zTU Dresden, Faculty of Medicine Carl Gustav Carus, Department of Medicine I/NCT/UCC Early Clinical Unit, Dresden, Germany

^aaDivision of Medical Oncology, National Cancer Centre Singapore, Singapore

^abDepartment of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan

^acGlobal Medical Affairs, Merck, Darmstadt, Germany

^adGlobal Clinical Development, Merck, Darmstadt, Germany

^aeGlobal Patient Safety, Merck, Darmstadt, Germany

^afDepartment of Biostatistics, Merck, Darmstadt, Germany

^agGlobal Value Demonstration, Market Access and Pricing, Merck, Darmstadt, Germany

^ahCompanion Diagnostics & Biomarker Strategy, Clinical Measurement Sciences, Merck, Darmstadt, Germany

^aiData Sciences, Clinical Measurement Sciences, Merck, Darmstadt, Germany

^ajQuantitative Pharmacology, Clinical Measurement Sciences, Merck, Darmstadt, Germany

^akQuantitative Pharmacology, Clinical Measurement Sciences, EMD Serono Research & Development Institute, Billerica, MA, USA, an affiliate of Merck

^alDepartment of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

^amSeoul National University Cancer Research Institute, Seoul, South Korea

^anDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea

^†INSIGHT 2 investigators are listed in the appendix (pp 2–3)

Correspondence to: Prof Yi-Long Wu, Prof Tae Min Kim