한빛사논문
서울대학교
Jae-Hwan Lee1, Jae-Young Bae1, Yoon-Nam Kim1, Minseong Chae1,2, Woo-Jin Lee1, Junsang Lee3, Im-Deok Kim1, Jung Keun Hyun4,5,6, Kang-Sik Lee7, Daeshik Kang8, Seung-Kyun Kang1,9,10,11
1Department of Materials Science and Engineering, Seoul National University, Seoul, 08826 Republic of Korea
2Biomedical Engineering Research Center, Asan Medical Center, Seoul, 05505 Republic of Korea
3Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907 USA
4Department of Nanobiomedical Science and BK21 NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, 31116 Republic of Korea
5Department of Rehabilitation Medicine, College of Medicine, Dankook University, Cheonan, 31116 Republic of Korea
6Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, 31116 Republic of Korea
7Biomedical Engineering Research Center, Asan Medical Center, Seoul, 05505 Republic of Korea
8Department of Mechanical Engineering, Ajou University, Suwon, 16499 Republic of Korea
9Interdisciplinary Program of Bioengineering, Seoul National University, Seoul, 08826 Republic of Korea
10Research Institute of Advanced Materials (RIAM), Seoul National University, Seoul, 08826 Republic of Korea
11Nano Systems Institute SOFT Foundry, Seoul National University, Seoul, 08826 Republic of Korea
J.-H.L. and J.-Y.B. contributed equally to this work.
Corresponding Authors: Kang-Sik Lee, Daeshik Kang, Seung-Kyun Kang
Abstract
A fully biodegradable, ultra-sensitive, and soft strain sensor is pivotal for temporary, real-time monitoring of microdeformations, crucial in disease diagnosis, surgical precision, and prognosis of muscular, and vascular conditions. Nevertheless, the strain sensitivity of previous biodegradable sensors, denoted by gauge factor (GF) up to ≈100, falls short of requirements for complex biomedical monitoring scenarios, specifically monitoring cardio-cerebrovascular diseases with microscale variations in vascular surface strain. Here, a fully biodegradable, ultra-sensitive crack-based flexible strain sensor is introduced achieving GF of 1355 at 1.5% strain through integration of molybdenum (Mo) film, molybdenum trioxide (MoO3) adhesion layer, and polycaprolactone (PCL) substrate. Analysis of crack morphology of biodegradable thin-film metals, including Mo, tungsten (W), and magnesium (Mg), reveals material-dependent sensitivity and repeatability of crack-based strain sensors. The effect of the adhesion layer and polymer substrate is also investigated. Overall morphological studies on the sensor present a comprehensive understanding of metal film cracking behavior and corresponding performance characterization, showing significant potential for highly sensitive sensors. A hybrid membrane composed of candelilla wax (Cw), beeswax (Bw), and polybutylene adipate-co-terephthalate (PBAT) is introduced to provide hydrophobic, yet flexible encapsulation. In vivo, short-term (≈3 days) monitoring of vascular pulsatility underscores the potential of the sensing tool for rapid, accurate, and temporal disease diagnosis and treatment.
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