최경환 (경상국립대학교)

한빛사논문

조회80

경상국립대학교

Ageing Res. Rev., Aug 05 2024, S1568-1637(24)00265-4 | https://doi.org/10.1016/j.arr.2024.102447 Overview Of a Novel Osmotin Abolishes Abnormal Metabolic-Associated Adiponectin Mechanism in Alzheimer's disease: Peripheral and CNS Insights

Inayat Ur Rehman ^a,1, Jun Sung Park ^a,1, Kyonghwan Choe ^a,b,1, Hyun Young Park ^b,c, Tae Ju Park ^d, Myeong Ok Kim ^a,e

^aDivision of Life Science and Applied Life Science (BK21 FOUR), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea

^bDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University, 6229 ER Maastricht, the Netherlands

^cDepartment of Pediatrics, Maastricht University Medical Center (MUMC+), 6202 AZ Maastricht, the Netherlands

^dHaemato-oncology/Systems Medicine Group, Paul O’Gorman Leukemia Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary & Life Sciences (MVLS), University of Glasgow, Glasgow G12 0ZD, United Kingdom

^eAlz-Dementia Korea Co., Jinju 52828, Republic of Korea

¹These authors contributed equally

Corresponding authors: Tae Ju Park, Myeong Ok Kim

Abstract

Alzheimer's disease (AD) is a degenerative brain disease that affects millions of people worldwide. It is caused by abnormalities in cholinergic neurons, oxidative stress, and inflammatory cascades. The illness is accompanied by personality changes, memory issues, and dementia. Metabolic signaling pathways help with fundamental processes like DNA replication and RNA transcription. Being adaptable is essential for both surviving and treating illness. The body's metabolic signaling depends on adipokines, including adiponectin (APN) and other adipokines secreted by adipose tissues. Energy homeostasis is balanced by adipokines, and nutrients. Overconsumption of nutrients messes with irregular signaling of adipokines, such as APN in both peripheral and brain which leads to neurodegeneration, such as AD. Despite the failure of traditional treatments like memantine and cholinesterase inhibitors, natural plant bioactive substances like Osmotin (OSM) have been given a focus as potential therapeutics due to their antioxidant properties, better blood brain barrier (BBB) permeability, excellent cell viability, and especially nanoparticle approaches. The review highlights the published preclinical literature regarding the role of OSM in AD pathology while there is a need for more research to investigate the hidden therapeutic potential of OSM which may open a new gateway and further strengthen its healing role in the pathogenesis of neurodegeneration, especially AD.

논문정보

형식Review Paper
게재일2024년 08월 (BRIC 등록일 2024-09-12)
연구진국내(교신)+국외 연구진
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