한빛사논문
- 조회156
Sung Young Kim a,b,c, Jaejoung Cheon a
aDepartment of Biochemistry, Konkuk University, Seoul 05029, South Korea
bResearch Institute of Medical Science, Seoul 05029, South Korea
cIBST, Konkuk University, Seoul 05029, South Korea
Correspondence to: Sung Young Kim
Abstract
The blood-brain barrier (BBB) and blood-retinal barrier (BRB) constitute critical physiochemical interfaces, precisely orchestrating the bidirectional communication between the brain/retina and blood. Increased permeability or leakage of these barriers has been demonstrably linked to age-related vascular and parenchymal damage. While it has been suggested that the gradual aging process may coincide with disruptions in these barriers, this phenomenon is significantly exacerbated in individuals with age-related neurodegenerative disorders (ARND). This review focuses on the microvascular endothelium, a key constituent of BBB and BRB, highlighting the impact of endothelial senescence on barrier dysfunction and exploring recent discoveries regarding core pathways implicated in its breakdown. Subsequently, we address the "vascular senescence hypothesis" for ARND, with a particular emphasis on Alzheimer's disease and age-related macular degeneration, centered on endothelial senescence. Finally, we discuss potential senotherapeutic strategies targeting barrier dysfunction.
논문정보
- Review Paper
- 2024년 08월 (BRIC 등록일 2024-08-16)
- 국내 연구진
- 생명과학 > 노화/암생물학
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