한빛사논문
- 조회156
Songling Jiang e, Han Sol Kim b, Ji Hyun Ryu b, Yong-Soo Lee c, Dong-Ik Kim d, Eun-Jung Jin a,e
aDepartment of Health Sciences, College of Health Sciences, Wonkwang University, Iksan, Jeonbuk 54538, South Korea
bDepartment of Chemical Engineering and Department of Carbon Convergence Engineering, Wonkwang University, Iksan, Jeonbuk 54538, South Korea
cResearch Center for Cartilage Regeneration, Barunsesang Hospital, Yatap-ro, Seongnam-si, Gyeonggi-do 13497, South Korea
dDivision of Vascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
eIntegrated Omics Institute, Wonkwang University, Iksan, Jeonbuk 54538, South Korea
Corresponding author : Eun-Jung Jin
Abstract
In this study, we report the rejuvenation of aged muscle fibers facilitated by heterochronic parabiosis, underscored by a notable upregulation in peroxisomal gene expression. Our findings highlight the pivotal role of dysregulation in peroxisomal biogenesis and consequential impairment of fatty acid β-oxidation in myoblast differentiation and muscle regeneration. Notably, we demonstrate the novel therapeutic strategy that involves the administration of peroxisome-COS-FITC complexes and nanozymes that mimic peroxisomal function, effectively rejuvenating aged muscle tissues. This innovative approach paves the way for new methods to mitigate or reverse sarcopenia, offering new avenues of the treatment of age-related muscle atrophy and a significant advancement in our understanding for the molecular underpinnings in muscle aging.
논문정보
- Research article
- 2024년 08월 (BRIC 등록일 2024-08-09)
- 국내 연구진
- 생명과학 > 노화/암생물학
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