김화중 (DGIST)

한빛사논문

조회103

김화중Hwajoong Kim

DGIST

Adv. Funct. Mater., 16 July 2024 | https://doi.org/10.1002/adfm.202402501 Bioelectronic Sutures with Electrochemical pH-Sensing for Long-Term Monitoring of the Wound Healing Progress

Hwajoong Kim¹, Jung Hyun Kim², Minji Jeong¹, Dongwook Lee^3,4, Jinho Kim¹, Mugeun Lee¹, Gain Kim⁵, Jayoung Kim³, Jung Seung Lee², Jaehong Lee¹

¹Department of Robotics and Mechatronics Engineering, DGIST, 333, Techno jungang-daero, Hyeonpung-eup, Dalseong-gun, Daegu, 42988 Republic of Korea

²Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University (SKKU), 2066 Seobu-ro, Jangan-gu, Suwon, 86211 Republic of Korea

³Department of Medical Engineering, College of Medicine, Yonsei University, 50, Yonsei-ro, Seodaemun-gu, Seoul, 03722 Republic of Korea

⁴Department of Chemistry, Yonsei University, 50, Yonsei-ro, Seodaemun-gu, Seoul, 03722 Republic of Korea

⁵Department of Electrical Engineering and Computer Science, DGIST, 333, Techno jungang-daero, Hyeonpung-eup, Dalseong-gun, Daegu, 42988 Republic of Korea

H.K. and J.H.K. contributed equally to this work.

Corresponding Authors: Jung Seung Lee, Jaehong Lee

Abstract

The physiological pH level at wound sites is one of the fundamental factors for monitoring wound conditions in clinical practice. To continuously assess the wound conditions, a variety of bioelectronic pH sensors are extensively developed. However, despite significant advances in bioelectronics for wound monitoring, the application of existing bioelectronic devices, primarily designed as bandages or patches, remains challenging for monitoring pH levels in deep wounds. Here, a flexible pH-sensing suture is introduced that can be simultaneously used as both a precise pH sensor for wound monitoring and a conventional medical suture. The electrochemical pH-sensing suture comprises Au nanoparticle-based flexible electrodes functionalized with polyaniline for the working electrode and Ag/AgCl for the reference electrode, seamlessly integrated onto a standard medical suturing thread. This dual-function sensing suture offers a reliable and high sensitivity of 58.9 mV pH−1, negligible hysteresis, high stability, and excellent selectivity in pH sensing. The biocompatibility of the sensing suture is systematically verified for its in vivo use. To demonstrate the capabilities of the pH-sensing suture, it is successfully applied to an incision and chronic wound model of mouse to perform continuous and accurate monitoring of the inflammation and healing progress of the wound throughout the healing period.

논문정보

형식Research article
게재일2024년 07월 (BRIC 등록일 2024-08-08)
연구진국내 연구진
분야 바이오·의료융합 > 바이오·의료융합 기타

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