이승욱 (University of California, Berkeley)

한빛사논문

조회150

University of California, Berkeley

CV File 76 kb

Nano Lett., Aug 05 2024, | https://doi.org/10.1021/acs.nanolett.4c02510 Virus-Based Separation of Rare Earth Elements

Inseok Chae^1,2, Arjun Shivkumar ¹, Fiona M Doyle ³, Seung-Wuk Lee^1,2

¹Department of Bioengineering, University of California, Berkeley, California 94720, United States.

²Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.

³Department of Materials Science and Engineering, University of California, Berkeley, California 94720, United States.

Corresponding Author : Seung-Wuk Lee

Abstract

The utilization of biomaterials for the separation of rare earth elements (REEs) has attracted considerable interest due to their inherent advantages, including diverse molecular structures for selective binding and the use of eco-friendly materials for sustainable systems. We present a pioneering methodology for developing a safe virus to selectively bind REEs and facilitate their release through pH modulation. We engineered the major coat protein of M13 bacteriophage (phage) to incorporate a lanthanide-binding peptide. The engineered lanthanide-binding phage (LBPh), presenting ∼3300 copies of the peptide, serves as an effective biological template for REE separation. Our findings demonstrate the LBPh's preferential binding for heavy REEs over light REEs. Moreover, the LBPh exhibits remarkable robustness with excellent recyclability and stability across multiple cycles of separations. This study underscores the potential of genetically integrating virus templates with selective binding motifs for REE separation, offering a promising avenue for environmentally friendly and energy-efficient separation processes.

논문정보

형식Research article
게재일2024년 08월 (BRIC 등록일 2024-08-06)
연구진국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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