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Trends Endocrinol. Metab., Aug 01 2024, S1043-2760(24)00185-1 | https://doi.org/10.1016/j.tem.2024.07.004
How obesity affects adipocyte turnover
Sang Mun Han 1, Hahn Nahmgoong 1, Kyung Min Yim 1, Jae Bum Kim 1
1National Leader Research Initiatives Center for Adipocyte Structure and Function, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University, Seoul 08826, Republic of Korea
Correspondence: Jae Bum Kim
Abstract
Cellular turnover is fundamental for tissue homeostasis and integrity. Adipocyte turnover, accounting for 4% of the total cellular mass turnover in humans, is essential for adipose tissue homeostasis during metabolic stress. In obesity, an altered adipose tissue microenvironment promotes adipocyte death. To clear dead adipocytes, macrophages are recruited and form a distinctive structure known as crown-like structure; subsequently, new adipocytes are generated from adipose stem and progenitor cells in the adipogenic niche to replace dead adipocytes. Accumulating evidence indicates that adipocyte death, clearance, and adipogenesis are sophisticatedly orchestrated during adipocyte turnover. In this Review, we summarize our current understandings of each step in adipocyte turnover, discussing its key players and regulatory mechanisms.
논문정보
- Review Paper
- 2024년 08월 (BRIC 등록일 2024-08-05)
- 국내 연구진
- 생명과학 > 분자생물학
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