한상문 (서울대학교)

한빛사논문

조회142

한상문Sang Mun Han

서울대학교

Trends Endocrinol. Metab., Aug 01 2024, S1043-2760(24)00185-1 | https://doi.org/10.1016/j.tem.2024.07.004 How obesity affects adipocyte turnover

Sang Mun Han ¹, Hahn Nahmgoong ¹, Kyung Min Yim ¹, Jae Bum Kim ¹

¹National Leader Research Initiatives Center for Adipocyte Structure and Function, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University, Seoul 08826, Republic of Korea

Correspondence: Jae Bum Kim

Abstract

Cellular turnover is fundamental for tissue homeostasis and integrity. Adipocyte turnover, accounting for 4% of the total cellular mass turnover in humans, is essential for adipose tissue homeostasis during metabolic stress. In obesity, an altered adipose tissue microenvironment promotes adipocyte death. To clear dead adipocytes, macrophages are recruited and form a distinctive structure known as crown-like structure; subsequently, new adipocytes are generated from adipose stem and progenitor cells in the adipogenic niche to replace dead adipocytes. Accumulating evidence indicates that adipocyte death, clearance, and adipogenesis are sophisticatedly orchestrated during adipocyte turnover. In this Review, we summarize our current understandings of each step in adipocyte turnover, discussing its key players and regulatory mechanisms.

논문정보

형식Review Paper
게재일2024년 08월 (BRIC 등록일 2024-08-05)
연구진국내 연구진
분야 생명과학 > 분자생물학

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