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Nat. Rev. Nephrol., Aug 02 2024, | https://doi.org/10.1038/s41581-024-00875-5
Lymphocytes and innate immune cells in acute kidney injury and repair
Kyungho Lee 1,2,3, Hye Ryoun Jang 1,3 & Hamid Rabb 2
1Division of Nephrology, Department of Medicine, Samsung Medical Center, Cell and Gene Therapy Institute, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
2Nephrology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
3These authors contributed equally: Kyungho Lee, Hye Ryoun Jang.
Corresponding author
Correspondence to Hamid Rabb.
Abstract
Acute kidney injury (AKI) is a common and serious disease entity that affects native kidneys and allografts but for which no specific treatments exist. Complex intrarenal inflammatory processes driven by lymphocytes and innate immune cells have key roles in the development and progression of AKI. Many studies have focused on prevention of early injury in AKI. However, most patients with AKI present after injury is already established. Increasing research is therefore focusing on mechanisms of renal repair following AKI and prevention of progression from AKI to chronic kidney disease. CD4+ and CD8+ T cells, B cells and neutrophils are probably involved in the development and progression of AKI, whereas regulatory T cells, double-negative T cells and type 2 innate lymphoid cells have protective roles. Several immune cells, such as macrophages and natural killer T cells, can have both deleterious and protective effects, depending on their subtype and/or the stage of AKI. The immune system not only participates in injury and repair processes during AKI but also has a role in mediating AKI-induced distant organ dysfunction. Targeted manipulation of immune cells is a promising therapeutic strategy to improve AKI outcomes.
논문정보
- Review Paper
- 2024년 08월 (BRIC 등록일 2024-08-05)
- 국내+국외 연구진
- 의약학 > 면역의학
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