장혜련 (성균관대학교 의과대학, 삼성서울병원)

한빛사논문

조회137

장혜련Hye Ryoun Jang

성균관대학교 의과대학, 삼성서울병원

Nat. Rev. Nephrol., Aug 02 2024, | https://doi.org/10.1038/s41581-024-00875-5 Lymphocytes and innate immune cells in acute kidney injury and repair

Kyungho Lee ^1,2,3, Hye Ryoun Jang ^1,3 & Hamid Rabb²

¹Division of Nephrology, Department of Medicine, Samsung Medical Center, Cell and Gene Therapy Institute, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

²Nephrology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

³These authors contributed equally: Kyungho Lee, Hye Ryoun Jang.

Corresponding author

Correspondence to Hamid Rabb.

Abstract

Acute kidney injury (AKI) is a common and serious disease entity that affects native kidneys and allografts but for which no specific treatments exist. Complex intrarenal inflammatory processes driven by lymphocytes and innate immune cells have key roles in the development and progression of AKI. Many studies have focused on prevention of early injury in AKI. However, most patients with AKI present after injury is already established. Increasing research is therefore focusing on mechanisms of renal repair following AKI and prevention of progression from AKI to chronic kidney disease. CD4⁺ and CD8⁺ T cells, B cells and neutrophils are probably involved in the development and progression of AKI, whereas regulatory T cells, double-negative T cells and type 2 innate lymphoid cells have protective roles. Several immune cells, such as macrophages and natural killer T cells, can have both deleterious and protective effects, depending on their subtype and/or the stage of AKI. The immune system not only participates in injury and repair processes during AKI but also has a role in mediating AKI-induced distant organ dysfunction. Targeted manipulation of immune cells is a promising therapeutic strategy to improve AKI outcomes.

논문정보

형식Review Paper
게재일2024년 08월 (BRIC 등록일 2024-08-05)
연구진국내+국외 연구진
분야 의약학 > 면역의학

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